Effects of collagen denaturation on the mechanical integrity of the collagen network in bone

Xiaodu Wang, Xiaoe Li, Xinmei Shen, Mitchell Larsen, Mauli C. Agrawal

Research output: Contribution to journalConference articlepeer-review

Abstract

A previous study showed that the mineral phase imparts the stiffness to bone, whereas the collagen network contributes to its toughness. A research was carried out to determine the effects of such changes in the collagen network on its mechanical integrity. Demineralized bone specimens which were pretreated by heating at 70°C were tested. It was observed that heating induced denaturation of collagen molecules shows impacts on all mechanical properties measured.

Original languageEnglish (US)
Pages (from-to)S-6
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering

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