Effects of chronic nocturnal opiate antagonism on the menstrual cycle

Robert G. Brzyski, Amabel Viniegra, David F. Archer

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


OBJECTIVE: Opioids generally suppress gonadotropin secretion. We investigated whether chronic opiate antagonism would affect the occurrence or timing of menstrual cycle events. STUDY DESIGN: Opiate blockade was maintained in nine normal volunteers from cycle days 1 through 13 with naltrexone. A double-blind, placebo-controlled crossover design was used. Serum estradiol and progesterone were measured daily. Vaginal ultrasonography was performed daily beginning cycle day 10. Endometrial biopsies were performed 10 to 12 days after ovulation. Nonparametric paired data analysis was used. RESULTS: No significant differences in the following menstrual cycle parameters were detected between naltrexone and placebo cycles: cycle length (25.4 ± 0.9 vs 25.7 ± 0.5 days), maximum follicle size (21.5 ± 1.0 vs 20.8 ± 1.1 mm), peak serum progesterone (15.8 ± 1.8 vs 15.2 ± 2.2 ng/ml), or integrated serum progesterone (108.1 ± 12.8 vs 101.2 ± 14.6 ng/ml/day). Histologic endometrial development was normal in all subjects during naltrexone cycles. CONCLUSION: These data suggest that naltrexone-suppressible opioid activity does not play a significant role in the regulation of follicular events in normal women.

Original languageEnglish (US)
Pages (from-to)1780-1784
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
StatePublished - Dec 1992
Externally publishedYes


  • corpus luteum
  • folliculogenesis
  • Menstrual cycle
  • opiate antagonists

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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