Effects of chronic fluvoxamine on ethanol- and food-maintained behaviors

Brett C Ginsburg, Richard J Lamb

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Acute treatment with fluvoxamine reduces responding for ethanol more than responding for food. However, pharmacotherapy for alcoholism is likely to require chronic treatment. These experiments were performed to assess the effects of chronic fluvoxamine on ethanol- and food-maintained behaviors. Effects of chronic fluvoxamine (10 and 17.8 mg/kg/day × 30 days) on ethanol- and food-maintained responding were compared to responding during saline treatment in four Sprague-Dawley rats responding for ethanol and food under a multiple fixed-ratio 5, fixed-ratio 5 schedule. In two subjects, chronic fluvoxamine reduced ethanol-maintained responding more than food-maintained responding; however this effect was transient. In another subject, treatment persistently decreased food-maintained responding relative to ethanol-maintained responding. Finally, in one subject, fluvoxamine nonspecifically disrupted responding for food and ethanol. Similar to results in humans, outbred Sprague-Dawley rats had differential responses to chronic fluvoxamine. The effect was transient in rats that responded favorably (greater reduction of ethanol relative to food responding), while response reductions persisted throughout treatment in rats that responded unfavorably (greater reduction of food relative to ethanol or nonspecific reductions).

Original languageEnglish (US)
Pages (from-to)1228-1233
Number of pages6
JournalLife Sciences
Volume79
Issue number13
DOIs
StatePublished - Aug 22 2006

Fingerprint

Fluvoxamine
Ethanol
Food
Rats
Sprague Dawley Rats
Drug therapy
Therapeutics
Alcoholism
Appointments and Schedules
Drug Therapy

Keywords

  • 5-HT
  • Alcohol
  • Operant
  • Selective serotonin reuptake inhibitor
  • Self-administration
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of chronic fluvoxamine on ethanol- and food-maintained behaviors. / Ginsburg, Brett C; Lamb, Richard J.

In: Life Sciences, Vol. 79, No. 13, 22.08.2006, p. 1228-1233.

Research output: Contribution to journalArticle

Ginsburg, Brett C ; Lamb, Richard J. / Effects of chronic fluvoxamine on ethanol- and food-maintained behaviors. In: Life Sciences. 2006 ; Vol. 79, No. 13. pp. 1228-1233.
@article{b24a00e1086d4eb296d1d52f1d4534e8,
title = "Effects of chronic fluvoxamine on ethanol- and food-maintained behaviors",
abstract = "Acute treatment with fluvoxamine reduces responding for ethanol more than responding for food. However, pharmacotherapy for alcoholism is likely to require chronic treatment. These experiments were performed to assess the effects of chronic fluvoxamine on ethanol- and food-maintained behaviors. Effects of chronic fluvoxamine (10 and 17.8 mg/kg/day × 30 days) on ethanol- and food-maintained responding were compared to responding during saline treatment in four Sprague-Dawley rats responding for ethanol and food under a multiple fixed-ratio 5, fixed-ratio 5 schedule. In two subjects, chronic fluvoxamine reduced ethanol-maintained responding more than food-maintained responding; however this effect was transient. In another subject, treatment persistently decreased food-maintained responding relative to ethanol-maintained responding. Finally, in one subject, fluvoxamine nonspecifically disrupted responding for food and ethanol. Similar to results in humans, outbred Sprague-Dawley rats had differential responses to chronic fluvoxamine. The effect was transient in rats that responded favorably (greater reduction of ethanol relative to food responding), while response reductions persisted throughout treatment in rats that responded unfavorably (greater reduction of food relative to ethanol or nonspecific reductions).",
keywords = "5-HT, Alcohol, Operant, Selective serotonin reuptake inhibitor, Self-administration, Serotonin",
author = "Ginsburg, {Brett C} and Lamb, {Richard J}",
year = "2006",
month = "8",
day = "22",
doi = "10.1016/j.lfs.2006.03.036",
language = "English (US)",
volume = "79",
pages = "1228--1233",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "13",

}

TY - JOUR

T1 - Effects of chronic fluvoxamine on ethanol- and food-maintained behaviors

AU - Ginsburg, Brett C

AU - Lamb, Richard J

PY - 2006/8/22

Y1 - 2006/8/22

N2 - Acute treatment with fluvoxamine reduces responding for ethanol more than responding for food. However, pharmacotherapy for alcoholism is likely to require chronic treatment. These experiments were performed to assess the effects of chronic fluvoxamine on ethanol- and food-maintained behaviors. Effects of chronic fluvoxamine (10 and 17.8 mg/kg/day × 30 days) on ethanol- and food-maintained responding were compared to responding during saline treatment in four Sprague-Dawley rats responding for ethanol and food under a multiple fixed-ratio 5, fixed-ratio 5 schedule. In two subjects, chronic fluvoxamine reduced ethanol-maintained responding more than food-maintained responding; however this effect was transient. In another subject, treatment persistently decreased food-maintained responding relative to ethanol-maintained responding. Finally, in one subject, fluvoxamine nonspecifically disrupted responding for food and ethanol. Similar to results in humans, outbred Sprague-Dawley rats had differential responses to chronic fluvoxamine. The effect was transient in rats that responded favorably (greater reduction of ethanol relative to food responding), while response reductions persisted throughout treatment in rats that responded unfavorably (greater reduction of food relative to ethanol or nonspecific reductions).

AB - Acute treatment with fluvoxamine reduces responding for ethanol more than responding for food. However, pharmacotherapy for alcoholism is likely to require chronic treatment. These experiments were performed to assess the effects of chronic fluvoxamine on ethanol- and food-maintained behaviors. Effects of chronic fluvoxamine (10 and 17.8 mg/kg/day × 30 days) on ethanol- and food-maintained responding were compared to responding during saline treatment in four Sprague-Dawley rats responding for ethanol and food under a multiple fixed-ratio 5, fixed-ratio 5 schedule. In two subjects, chronic fluvoxamine reduced ethanol-maintained responding more than food-maintained responding; however this effect was transient. In another subject, treatment persistently decreased food-maintained responding relative to ethanol-maintained responding. Finally, in one subject, fluvoxamine nonspecifically disrupted responding for food and ethanol. Similar to results in humans, outbred Sprague-Dawley rats had differential responses to chronic fluvoxamine. The effect was transient in rats that responded favorably (greater reduction of ethanol relative to food responding), while response reductions persisted throughout treatment in rats that responded unfavorably (greater reduction of food relative to ethanol or nonspecific reductions).

KW - 5-HT

KW - Alcohol

KW - Operant

KW - Selective serotonin reuptake inhibitor

KW - Self-administration

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=33746899379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746899379&partnerID=8YFLogxK

U2 - 10.1016/j.lfs.2006.03.036

DO - 10.1016/j.lfs.2006.03.036

M3 - Article

C2 - 16647721

AN - SCOPUS:33746899379

VL - 79

SP - 1228

EP - 1233

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 13

ER -