Effects of celox andtraumaDEX on hemorrhage control in a porcine model

Brian T. Gegel, James M. Burgert, Cheryl Lockhart, Robert Austin, Alejandro Davila, Jacob Deeds, Lonnie Hodges, Andrew Hover, John Roy, Glenn Simpson, Stephen Weaver, William Wolfe, Don Johnson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The purpose of this study was to compare the effectiveness of 2 hemostatic agents, chitosan-based Celox and the biopolymeric, microporous particles Trau-maDEX, with a control group in a porcine model of hemorrhage. The animals were randomly assigned to 1 of 3 groups: Celox (n = 5), TraumaDEX (n = 5), or a standard pressure dressing alone (n = 5). To simulate a battlefield injury, the investigators generated a compound groin injury with transection of the femoral artery and vein in 15 pigs. After 1 minute of uncontrolled hemorrhage, Celox or TraumaDEX was poured into the wound, followed by standard wound packing. The control group underwent the same procedures with the exception of the hemostatic agents. In all groups, 5 minutes of direct manual pressure was applied to the wound, followed by a standard pressure dressing (3M Coban). After 30 minutes, dressings were removed, and the amount of bleeding was measured. There were statistically significant differences in bleeding between Celox and control (P = .01) and between TraumaDEX and control (P = .038), but no statistically significant difference in bleeding between Celox andTraumaDEX (P = .478). Celox andTraumaDEX may be effective hemostatic agents for use in civilian and military trauma.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalAANA Journal
Volume78
Issue number2
StatePublished - Apr 2010
Externally publishedYes

Keywords

  • Celox
  • Hemostasis
  • Hemostatic agents
  • TraumaDEX
  • Uncontrolled hemorrhage

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

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