Effects of carbamazepine on plasma haloperidol levels

Michael W. Jann, Larry Ereshefsky, Stephen R. Saklad, Donald R. Seidel, Chester M. Davis, Neil R. Burch, Charles L. Bowden

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90 Scopus citations

Abstract

Plasma haloperidol levels were monitored in three schizophrenic patients when carbamazepine was either added or discontinued. The percent decrease in plasma haloperidol levels due to concomitant carbamazepine therapy was between 59% and 61%. The effects of carbamazepine on plasma haloperidol levels were noted to occur in 2 to 3 weeks. Although no adverse effects occurred in the patients during therapy, careful monitoring of clinical symptoms and plasma haloperidol levels is recommended.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume5
Issue number2
DOIs
Publication statusPublished - Apr 1985

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ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Jann, M. W., Ereshefsky, L., Saklad, S. R., Seidel, D. R., Davis, C. M., Burch, N. R., & Bowden, C. L. (1985). Effects of carbamazepine on plasma haloperidol levels. Journal of Clinical Psychopharmacology, 5(2), 106-109. https://doi.org/10.1097/00004714-198504000-00010