We examined the effects of long term antihypertensive drug treatment on spontaneously hypertensive (SH) rats. Methods: At 4 months of age, SH rats were randomized into 3 groups: captopril 90 mg/kg/day (n=6), propranolol 80 mg/kg/day (n=9), and control (n=13). The drugs were dissolved in drinking water. Cognitive function in the rats was evaluated by means of the Morris Water Maze (a test of spatial memory) at baseline (2 months) and at 12 months and 19 months of age. Regional cerebral blood flow (rCBF) was measured by the 14C-iodoantipyrine method. Results: Body weight, water intake, and systolic blood pressure were all significantly higher in control animals than for the drug-treated animals at 12 months and 19 months. On routine training tests, the propranolol group showed a significantly worse performance at 19 months (p=.026) compared to 12 months. The propranolol group also performed significantly worse than either the captopril (p=.034) or the control group (p=.013) at 19 months. Parietal cortex rCBF was 47% lower in 19 month old propranolol-treated rats than in control rats (p=.018). Cognitive performance and rCBF in the captopril group were not significantly different from control. We conclude that with regard to cognitive function and rCBF, propranolol may have adverse effects in older animals with chronic hypertension.
|Original language||English (US)|
|Journal||Journal of Investigative Medicine|
|State||Published - Jan 1 1996|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)