Effects of caerulein + haloperidol on amphetamine-induced locomotor stereotypy in rats

Kathyrne Mueller, Jennifer L. Peel, Kirsten L. Rewey

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The combination of haloperidol + caerulein has been reported to produce a long-lasting reduction of amphetamine-induced hyperlocomotions in rats. This study was designed to replicate those findings and to determine whether haloperidol + caerulein produce any unique effect on amphetamine-induced locomotor stereotypy. In two experiments, haloperidol + caerulein failed to produce a long-lasting reduction in amphetamine-induced hyperlocomotions. Although haloperidol reduced the locomotor stereotypy produced by higher doses of amphetamine, caerulein had no effect, either alone or combined with haloperidol.

Original languageEnglish (US)
Pages (from-to)717-724
Number of pages8
JournalLife Sciences
Volume44
Issue number11
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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