Effects of burns on inhalation injury in sheep: A 5-day study

Osamu Tasaki, Michael A. Dubick, Cleon W. Goodwin, Basil A. Pruitt

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background We have previously reported that infliction of thermal injury immediately after smoke exposure did not accentuate pulmonary dysfunction during the subsequent 48 h. The purpose of this study was to determine whether thermal injury would aggravate pulmonary dysfunction during a longer postinjury period of 5 days. Methods Six sheep (G1) received 12 units of smoke inhalation injury (SII) alone; seven sheep (G2) received a 40% full-thickness scald burn immediately after SII. All sheep were resuscitated with lactated Ringer’s solution for the first 48 h. After 48 h, animals were fed food and water ad libitum. Cardiopulmonary variables and blood gases were measured serially. At the end of the 5-day experimental period, Va/Q distribution was analyzed using the multiple inert gas elimination technique (MIGET). Lung wet to dry (W/D) weight ratios and malondialdehyde (MDA) concentrations were determined. Results Cardiac index in G2 significantly increased and remained higher compared with G1. There was no difference in A-aDo2 between the two groups. There was also no difference between the two groups by MIGET study, or in terms of lung MDA and W/D weight ratios. None of the animals manifested symptoms of infection.Conclusion Despite the difference in the hemodynamic changes induced by the addition of a 40% burn to smoke inhalation injury, pulmonary dysfunction was not accentuated during the 5-day study period in the absence of infection.

Original languageEnglish (US)
Pages (from-to)351-358
Number of pages8
JournalJournal of Trauma
Issue number2
StatePublished - Feb 2002


  • Malondialdehyde
  • Multiple inert gas elimination technique (MIGET)
  • Sheep
  • Smoke inhalation
  • Thermal injury

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine


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