Effects of buprenorphine on behavior maintained by heroin and alfentanil in rhesus monkeys

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The mechanism by which buprenorphine reduces opioid self-administration in humans and animals is generally thought to be through its opioid agonist effects. Buprenorphine, given acutely i.v. to three rhesus monkeys 30 min prior to a session in which a range of doses of either alfentanil or heroin was available, produced dose-related decreases in the potency of both opioid agonists. The effects of buprenorphine were generally surmounted by increasing the dose/injection of alfentanil or heroin available for self-administration, indicating that buprenorphine was acting as an opioid antagonist in this situation. These data suggest that at least part of the effectiveness of buprenorphine in reducing opioid administration by human opioid users may be via its opioid antagonist properties.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalBehavioural pharmacology
Volume7
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Alfentanil
  • Buprenorphine
  • Heroin
  • Rhesus monkey
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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