Effects of buprenorphine and other opioid agonists and antagonists on alfentanil- and cocaine-reinforced responding in rhesus monkeys

G. Winger, P. Skjoldager, J. H. Woods

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Rhesus monkeys self-administered a range of doses of either cocaine or alfentanil under a fixed-ratio 30, time out 45 sec schedule of i.v. drug delivery. Buprenorphine suppressed responding maintained by both cocaine and alfentanil; however, much larger doses of buprenorphine were required to suppress cocaine-reinforced as opposed to alfentanil-reinforced responding. Neither cocaine nor alfentanil dose-effect curves were shifted to the right by buprenorphine, but were simply shifted downward. Opioid agonists heroin and nalbuphine produced similar downward shifts in both alfentanil and cocaine dose-effect curves; unlike buprenorphine, similar doses of heroin and nalbuphine suppressed behavior maintained by both cocaine and alfentanil. Increasing doses of the pure opioid antagonist quadazocine produced shifts to the right in the alfentanil rate-maintaining dose-effect curves but had no dose-related effect on behavior maintained by cocaine. The data suggest that buprenorphine suppresses drug-maintained responding through an agonist action but that alfentanil-maintained responding is uniquely sensitive to buprenorphine's effects.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume261
Issue number1
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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