Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters.

M. K. Vaughan; M. C. Powanda; G. C. Brainard; L. Y. Johnson; R. J. Reiter

Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters.

M. K. Vaughan, M. C. Powanda, G. C. Brainard, L. Y. Johnson, R. J. Reiter

Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Adult male and female hamsters (Mesocricetus auratus) were divided into 3 treatment groups: intact, blinded, and intact hamsters which received daily sc injections of 25 microgram melatonin (MEL) at 1700 h. After 10 weeks of treatment, thyroxine (T4), triiodothyronine (T3) and cholesterol levels in both male and female blinded or MEL-treated animals were depressed compared to plasma titers of their respective intact control groups. Plasma thyrotropin (TSH) levels were depressed by MEL treatment but unaffected by blinding in male hamsters; in contrast, blinded or MEL-treated female hamsters had significantly higher TSH levels than the control group. Plasma triglyceride levels were depressed by both blinding and MEL-treatment in males but were unaffected in females.

Original language	English (US)
Pages (from-to)	177-186
Number of pages	10
Journal	Progress in clinical and biological research
Volume	92
State	Published - Jan 1 1982

ASJC Scopus subject areas

Medicine(all)

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Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters. / Vaughan, M. K.; Powanda, M. C.; Brainard, G. C.; Johnson, L. Y.; Reiter, R. J.

In: Progress in clinical and biological research, Vol. 92, 01.01.1982, p. 177-186.

Research output: Contribution to journal › Article › peer-review

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abstract = "Adult male and female hamsters (Mesocricetus auratus) were divided into 3 treatment groups: intact, blinded, and intact hamsters which received daily sc injections of 25 microgram melatonin (MEL) at 1700 h. After 10 weeks of treatment, thyroxine (T4), triiodothyronine (T3) and cholesterol levels in both male and female blinded or MEL-treated animals were depressed compared to plasma titers of their respective intact control groups. Plasma thyrotropin (TSH) levels were depressed by MEL treatment but unaffected by blinding in male hamsters; in contrast, blinded or MEL-treated female hamsters had significantly higher TSH levels than the control group. Plasma triglyceride levels were depressed by both blinding and MEL-treatment in males but were unaffected in females.",

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AU - Johnson, L. Y.

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Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters.

Abstract

ASJC Scopus subject areas

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