Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters.

M. K. Vaughan, M. C. Powanda, G. C. Brainard, L. Y. Johnson, R. J. Reiter

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Adult male and female hamsters (Mesocricetus auratus) were divided into 3 treatment groups: intact, blinded, and intact hamsters which received daily sc injections of 25 microgram melatonin (MEL) at 1700 h. After 10 weeks of treatment, thyroxine (T4), triiodothyronine (T3) and cholesterol levels in both male and female blinded or MEL-treated animals were depressed compared to plasma titers of their respective intact control groups. Plasma thyrotropin (TSH) levels were depressed by MEL treatment but unaffected by blinding in male hamsters; in contrast, blinded or MEL-treated female hamsters had significantly higher TSH levels than the control group. Plasma triglyceride levels were depressed by both blinding and MEL-treatment in males but were unaffected in females.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalProgress in clinical and biological research
Volume92
StatePublished - Jan 1 1982

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this