Effects of b-FNA in drug-naive and morphine-dependent rhesus monkeys

D. Gmerek, J. H. Woods

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The β-fumarate methyl ester of naltrexone, β-FNA has been reported to be a selective non-equilibrium opiate mu receptor antagonist and reversible kappa receptor agonist in vitro and in vivo. These properties would make β-FNA very useful as a pharmacologic probe. However, the pharmacology of this interesting compound has not yet been characterized extensively. In this work, we have studied β-FNA by observing its overt behavioral effects in drug-naive and morphine-dependent rhesus monkeys. It was compared to the chemically related narcotic antagonist naltrexone. β-FAN appears to reach sites in the central nervous system after systemic administration in small amounts compared to naltrexone; we find β-FNA to be an insurmountable mu receptor-selective antagonist in the rhesus monkey.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalNIDA Research Monograph Series
VolumeNO. 55
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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