Effects of arterial stiffness on brain integrity in young adults from the framingham heart study

Pauline Maillard, Gary F. Mitchell, Jayandra J. Himali, Alexa Beiser, Connie W. Tsao, Matthew P. Pase, Claudia L. Satizabal, Ramachandran S. Vasan, Sudha Seshadri, Charles De Carli

Research output: Contribution to journalArticle

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Abstract

Background and Purpose-Previous work from the Framingham Heart Study suggests that brain changes because of arterial aging may begin in young adulthood and that such changes precede cognitive deficits. The objective of this study was to determine the association of arterial stiffness with measures of white matter and gray matter (GM) integrity in young adults. Methods-One thousand nine hundred three participants from the Framingham Heart Study Third Generation (mean age, 46±8.7 years) had complete tonometry measurements and brain magnetic resonance imaging (T1-weighted and diffusion tensor imaging). Tonometry measures included carotid-femoral pulse wave velocity, augmentation index, carotidbrachial pressure amplification, and central pulse pressure. Fractional anisotropy and GM density images were computed from diffusion tensor imaging and T1 images. Registration to a common anatomic template enabled voxel-based linear regressions relating measures of fractional anisotropy and GM to tonometry measures, adjusting for relevant covariables. Results-Higher carotid-femoral pulse wave velocity was associated with lower regional fractional anisotropy, including the corpus callosum and the corona radiata (8.7 and 8.6 cc, respectively, P<0.001), as well as lower GM density in the thalamus region (0.9 cc, P<0.001). Analyses did not reveal significant associations between other tonometry measures and fractional anisotropy or GM. Conclusions-Among young healthy adults, higher aortic stiffness was associated with measures of reduced white matter and GM integrity in areas implicated in cognitive decline and Alzheimer's disease. Greater aortic stiffness may result in subclinical vascular brain injury at ages much younger than previously described.

Original languageEnglish (US)
Pages (from-to)1030-1036
Number of pages7
JournalStroke
Volume47
Issue number4
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Vascular Stiffness
Young Adult
Anisotropy
Manometry
Brain
Pulse Wave Analysis
Diffusion Tensor Imaging
Thigh
Cerebrovascular Trauma
Corpus Callosum
Thalamus
Gray Matter
Linear Models
Alzheimer Disease
Magnetic Resonance Imaging
Blood Pressure
Pressure

Keywords

  • Blood pressure
  • Brain
  • Diffusion tensor imaging
  • Magnetic resonance imaging
  • White matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Maillard, P., Mitchell, G. F., Himali, J. J., Beiser, A., Tsao, C. W., Pase, M. P., ... De Carli, C. (2016). Effects of arterial stiffness on brain integrity in young adults from the framingham heart study. Stroke, 47(4), 1030-1036. https://doi.org/10.1161/STROKEAHA.116.012949

Effects of arterial stiffness on brain integrity in young adults from the framingham heart study. / Maillard, Pauline; Mitchell, Gary F.; Himali, Jayandra J.; Beiser, Alexa; Tsao, Connie W.; Pase, Matthew P.; Satizabal, Claudia L.; Vasan, Ramachandran S.; Seshadri, Sudha; De Carli, Charles.

In: Stroke, Vol. 47, No. 4, 01.01.2016, p. 1030-1036.

Research output: Contribution to journalArticle

Maillard, P, Mitchell, GF, Himali, JJ, Beiser, A, Tsao, CW, Pase, MP, Satizabal, CL, Vasan, RS, Seshadri, S & De Carli, C 2016, 'Effects of arterial stiffness on brain integrity in young adults from the framingham heart study', Stroke, vol. 47, no. 4, pp. 1030-1036. https://doi.org/10.1161/STROKEAHA.116.012949
Maillard P, Mitchell GF, Himali JJ, Beiser A, Tsao CW, Pase MP et al. Effects of arterial stiffness on brain integrity in young adults from the framingham heart study. Stroke. 2016 Jan 1;47(4):1030-1036. https://doi.org/10.1161/STROKEAHA.116.012949
Maillard, Pauline ; Mitchell, Gary F. ; Himali, Jayandra J. ; Beiser, Alexa ; Tsao, Connie W. ; Pase, Matthew P. ; Satizabal, Claudia L. ; Vasan, Ramachandran S. ; Seshadri, Sudha ; De Carli, Charles. / Effects of arterial stiffness on brain integrity in young adults from the framingham heart study. In: Stroke. 2016 ; Vol. 47, No. 4. pp. 1030-1036.
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abstract = "Background and Purpose-Previous work from the Framingham Heart Study suggests that brain changes because of arterial aging may begin in young adulthood and that such changes precede cognitive deficits. The objective of this study was to determine the association of arterial stiffness with measures of white matter and gray matter (GM) integrity in young adults. Methods-One thousand nine hundred three participants from the Framingham Heart Study Third Generation (mean age, 46±8.7 years) had complete tonometry measurements and brain magnetic resonance imaging (T1-weighted and diffusion tensor imaging). Tonometry measures included carotid-femoral pulse wave velocity, augmentation index, carotidbrachial pressure amplification, and central pulse pressure. Fractional anisotropy and GM density images were computed from diffusion tensor imaging and T1 images. Registration to a common anatomic template enabled voxel-based linear regressions relating measures of fractional anisotropy and GM to tonometry measures, adjusting for relevant covariables. Results-Higher carotid-femoral pulse wave velocity was associated with lower regional fractional anisotropy, including the corpus callosum and the corona radiata (8.7 and 8.6 cc, respectively, P<0.001), as well as lower GM density in the thalamus region (0.9 cc, P<0.001). Analyses did not reveal significant associations between other tonometry measures and fractional anisotropy or GM. Conclusions-Among young healthy adults, higher aortic stiffness was associated with measures of reduced white matter and GM integrity in areas implicated in cognitive decline and Alzheimer's disease. Greater aortic stiffness may result in subclinical vascular brain injury at ages much younger than previously described.",
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AU - Pase, Matthew P.

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