Effects of arterial blood pressure on rebleeding using Celox and traumaDEX in a porcine model of lethal femoral injury

James M. Burgert, Brian T. Gegel, Robert Austin, Alejandro Davila, Jacob Deeds, Lonnie Hodges, Andrew Hover, Cheryl Lockhart, John Roy, Glenn Simpson, Stephen Weaver, William Wolfe, Don Johnson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

This study was designed to identify the systolic blood pressure (SBP) and mean arterial pressure (MAP) at which rebleeding occurs when a clot is formed by a hemostatic agent, Celox or TraumaDEX, compared with a standard dressing. Fifteen pigs (5 each) were assigned randomly to 1 of 3 groups: Celox, TraumaDEX, or standard pressure dressing as a control. In all animals, the femoral artery and vein were transected to simulate traumatic injury. Subjects were allowed to hemorrhage 1 minute before treatment. Direct pressure was held 5 minutes followed by application of elastic dressings for 30 minutes. Dressings were removed after 30 minutes, and the wound was observed for rebleeding. Animals demonstrating hemostasis received phenylephrine infusion to increase SBP in 10-mm Hg increments until SBP reached 210 mm Hg or hemorrhage recurred. There were statistically significant differences between Celox (mean SBP, 166.4 mm Hg; mean MAP, 137.6 mm Hg) and the control (mean SBP, 88.25 mm Hg; mean MAP, 59.7 mm Hg), and between TraumaDEX (mean SBP, 152.2 mm Hg; mean MAP, 113.2 mm Hg) and the control (P < .05). However, no statistically significant difference existed between Celox and TraumaDEX. Celox and TraumaDEX effectively prevent rebleeding compared with standard dressing.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalAANA Journal
Volume78
Issue number3
StatePublished - Jun 1 2010
Externally publishedYes

Keywords

  • Celox
  • Hemorrhage
  • Hemostatic agent
  • Rebleeding
  • TraumaDEX

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

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    Burgert, J. M., Gegel, B. T., Austin, R., Davila, A., Deeds, J., Hodges, L., Hover, A., Lockhart, C., Roy, J., Simpson, G., Weaver, S., Wolfe, W., & Johnson, D. (2010). Effects of arterial blood pressure on rebleeding using Celox and traumaDEX in a porcine model of lethal femoral injury. AANA Journal, 78(3), 230-236.