Effects of amphetamine, morphine, and CP 55, 940 on Go/No-Go task performance in rhesus monkeys

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In humans, impulsivity measured as false alarms in a Go/No-Go task is reportedly decreased by amphetamine and is not affected by oxycodone and delta(9)-tetrahydrocannabinol. To model these findings in animals, three rhesus monkeys were trained to perform a food-reinforced Go/No-Go task. In this task, amphetamine was found to decrease false alarms (i.e. responding during No-Go trials), but only at doses that also decreased hits (i.e. responding during Go trials). Morphine generally decreased hits but not false alarms. The cannabinoid receptor agonist CP 55, 940 decreased both false alarms and hits, but only at doses that also decreased the number of trials completed. Additional studies in animals and humans are necessary to delineate the conditions under which amphetamine and other psychoactive drugs affect impulsivity in Go/No-Go tasks.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalBehavioural Pharmacology
Volume26
Issue number5
DOIs
StatePublished - Aug 8 2015

Fingerprint

Task Performance and Analysis
Amphetamine
Macaca mulatta
Morphine
Impulsive Behavior
Oxycodone
Cannabinoid Receptor Agonists
Dronabinol
Psychotropic Drugs
Food
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol

Keywords

  • 940
  • amphetamine
  • CP 55
  • Go/No-Go task
  • impulsivity
  • morphine
  • rhesus monkeys

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Effects of amphetamine, morphine, and CP 55, 940 on Go/No-Go task performance in rhesus monkeys. / Koek, Wouter; Gerak, Lisa R; France, Charles P.

In: Behavioural Pharmacology, Vol. 26, No. 5, 08.08.2015, p. 481-484.

Research output: Contribution to journalArticle

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