Effects of Aloe vera ingestion in the rat. II. Hormonal and metabolic characteristics

J. T. Herlihy, J. D. Kim, D. N. Kalu, J. F. Nelson, W. F. Ward, Y. Ikeno, B. P. Yu

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13 Scopus citations


The aim of this study was to examine the effects of long-term (1.5 and 5.5 months) Aloe vera (Aloe barbadensis) ingestion on a variety of metabolic parameters of Fischer 344 male rats. Rats were fed Aloe vera powders produced by two different methods and mixed with rat chow at various concentrations. Process A Aloe was prepared from skinned Aloe filets by homogenization followed by lyophilization and included in the rat chow at the 1% level. Process B Aloe was prepared similarly except the homogenate was charcoal filtered prior to lyophilization and mixed with chow at both 1% and 10% levels. Plasma concentrations of parathyroid hormone (PTH) and calcitonin were lower in the older (7 month) Aloe fed than in the control rats of the same age. No statistically significant effects were observed at the younger age (3 month). Aloe feeding did not alter the plasma glucose and insulin levels at any age and had only minor effects on the plasma corticosterone concentrations in the older rats. Serum lipid peroxides were decreased by Aloe feeding, but the malondialdehyde production of cardiac and hepatic mitochondrial and microsomal membranes were unaffected. No alteration in protein turnover was observed in the Aloe fed rats.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalPhytotherapy Research
Issue number5
StatePublished - Aug 1998


  • Calcitonin
  • Glucose
  • Insulin
  • Lipid peroxides
  • Malondialdehyde
  • Parathyroid hormone
  • Protein turnover

ASJC Scopus subject areas

  • Pharmacology


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