Effects of aging and food restriction on the trigeminal ganglion: A morphometric study

M. A. Biedenbach, D. N. Kalu, D. C. Herbert

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A quantitative morphometric study of the rat trigeminal ganglion was conducted to determine the changes that occur with aging. All measurements were tracked from young to old age in two rat groups simultaneously. One group was fed ad libitum, the other was maintained on restricted food intake from 6 weeks on. Immunocytochemical and radioimmunoassay techniques were used to study the neuron group that produces the peptide, CGRP and to compare it with the CGRP-negative neuron group. We observed that in the trigeminal ganglion, soma diameters and nucleus diameters of all neurons, whether CGRP positive or negative, increased modestly with age; so did total ganglion weight. Food restriction delayed, but did not prevent the increases in neuron diameters. No significant changes occurred as a function of age in the total number of neurons per ganglion, the ratio of CGRP positive to CGRP negative neurons and ganglion content of CGRP. Food restriction did not affect the parameters that remained constant with age. These findings are in contrast to the marked inhibitory effect of food restriction on age-related increase in thyroid calcitonin, a hormone that is encoded by the same gene as CGRP.

Original languageEnglish (US)
Pages (from-to)111-125
Number of pages15
JournalMechanisms of Ageing and Development
Issue number2-3
StatePublished - Sep 1992
Externally publishedYes


  • Aging
  • CGRP
  • Fisher 344 male rat
  • food restriction
  • Neuron numbers
  • Neuron size
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


Dive into the research topics of 'Effects of aging and food restriction on the trigeminal ganglion: A morphometric study'. Together they form a unique fingerprint.

Cite this