Abstract
The authors hypothesized that rat plasma or tissue glutathione metabolism could change with age due to possible decreases in glutathione-related enzyme activities. To test this hypothesis, the authors measured plasma and tissue concentrations of glutathione and glutathione-related enzymes. Animals were 3 months, 12 months, or 24 months old at the time of experiments. Plasma glutathione was found to be significantly increased in both the 12-month-old and 24-month-old groups compared to the 3-month-old rats. Tissue enzyme measurements showed no significant differences between the groups in lung or liver glutathione peroxidase or glutathione S-transferase. γ-Glutamyl transpeptidase activity was significantly decreased in kidney and lung with aging. Decreases in tissue γ-glutamyl transpeptidase activity occur with age; this may contribute to increases in plasma glutathione concentrations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 347-352 |
| Number of pages | 6 |
| Journal | American Journal of the Medical Sciences |
| Volume | 302 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1991 |
| Externally published | Yes |
Keywords
- Aging rats
- Gamma-glutamyl transpeptidase
- Glutathione
- Glutathione peroxidase
ASJC Scopus subject areas
- Medicine(all)