Effects of age on rat glutathione metabolism

S. G. Jenkinson, C. A. Duncan, C. L. Bryan, R. A. Lawrence

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The authors hypothesized that rat plasma or tissue glutathione metabolism could change with age due to possible decreases in glutathione-related enzyme activities. To test this hypothesis, the authors measured plasma and tissue concentrations of glutathione and glutathione-related enzymes. Animals were 3 months, 12 months, or 24 months old at the time of experiments. Plasma glutathione was found to be significantly increased in both the 12-month-old and 24-month-old groups compared to the 3-month-old rats. Tissue enzyme measurements showed no significant differences between the groups in lung or liver glutathione peroxidase or glutathione S-transferase. γ-Glutamyl transpeptidase activity was significantly decreased in kidney and lung with aging. Decreases in tissue γ-glutamyl transpeptidase activity occur with age; this may contribute to increases in plasma glutathione concentrations.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalAmerican Journal of the Medical Sciences
Issue number6
StatePublished - 1991
Externally publishedYes


  • Aging rats
  • Gamma-glutamyl transpeptidase
  • Glutathione
  • Glutathione peroxidase

ASJC Scopus subject areas

  • Medicine(all)


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