Effects of acute and chronic flunitrazepam on delay discounting in pigeons

Amy K. Eppolito, Charles P. France, Lisa R. Gerak

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Delay to delivery of a reinforcer can decrease responding for that reinforcer and increase responding for smaller reinforcers that are available concurrently and delivered without delay; acute administration of drugs can alter responding for large, delayed reinforcers, although the impact of chronic treatment on delay discounting is not well understood. In this experiment, the effects of repeated administration of the benzodiazepine flunitrazepam were studied in 6 pigeons responding on one key to receive food that was delivered immediately and on a second key to receive a larger amount of food that was delivered following delays which increased across a single session. Pigeons responded predominantly for the large reinforcer when there were no delays and when delays were short; however, as delays increased, responding for the large reinforcer decreased. Acutely, flunitrazepam (0.32, 1.0 and 3.2 mg/kg) dose-dependently increased responding for the large reinforcer, shifting the discounting curve rightward and upward. Repeated administration of flunitrazepam (0.32, 1.0 and 3.2 mg/kg, each for six sessions, separated by one session during which vehicle was administered) did not markedly alter its effects on responding for the large reinforcer, indicating that the development of tolerance to this effect of flunitrazepam is modest under these conditions.

Original languageEnglish (US)
Pages (from-to)163-174
Number of pages12
JournalJournal of the experimental analysis of behavior
Volume95
Issue number2
DOIs
Publication statusPublished - Jul 20 2011

    Fingerprint

Keywords

  • Delay discounting
  • Fixed delays
  • Flunitrazepam
  • Key peck
  • Pigeons
  • Tolerance

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this