TY - JOUR
T1 - Effects of a novel fentanyl derivative on drug discrimination and learning in rhesus monkeys
AU - Gerak, Lisa R.
AU - Moerschbaecher, Joseph M.
AU - Bagley, Jerome R.
AU - Brockunier, Linda L.
AU - France, Charles P.
N1 - Funding Information:
This work was supported by USPHS Grants DA05018, and DA03573. CPF is the recipient of a Research Scientist Development Award (DA00211). Animals used in these studies were maintained in accordance with the Institutional Animal Care and Use Committee, Louisiana State University Medical Center and guidelines of the Committee on Care and Use of Laboratory Animal Resources, National Research Council (Department of Health, Education and Welfare, Publication NO. (NIH) 85-23, revised 1996).
PY - 1999/10
Y1 - 1999/10
N2 - Three monkeys discriminated 1.78 mg/kg of mirfentanil while responding under a fixed-ratio 5 schedule of stimulus-shock termination. Two mirfentanil derivatives, OHM3295 and OHM10579, substituted for mirfentanil in all subjects. However, other drugs produced variable effects among monkeys; for example, μ and κ opioid agonists and clonidine substituted for mirfentanil on some occasions in two monkeys. Cocaine, amphetamine, and ketamine did not substitute in any subject. Opioid antagonists did not attenuate the effects of mirfentanil. In monkeys responding under a repeated acquisition and performance procedure, errors increased only during the acquisition phase at doses of mirfentanil that decreased response rates. Thus, unlike fentanyl, the discriminative stimulus effects of mirfentanil do not appear to be mediated exclusively through opioid receptors. Finally, mirfentanil does not appear to disrupt complex behavioral processes. Copyright (C) 1999 Elsevier Science Inc.
AB - Three monkeys discriminated 1.78 mg/kg of mirfentanil while responding under a fixed-ratio 5 schedule of stimulus-shock termination. Two mirfentanil derivatives, OHM3295 and OHM10579, substituted for mirfentanil in all subjects. However, other drugs produced variable effects among monkeys; for example, μ and κ opioid agonists and clonidine substituted for mirfentanil on some occasions in two monkeys. Cocaine, amphetamine, and ketamine did not substitute in any subject. Opioid antagonists did not attenuate the effects of mirfentanil. In monkeys responding under a repeated acquisition and performance procedure, errors increased only during the acquisition phase at doses of mirfentanil that decreased response rates. Thus, unlike fentanyl, the discriminative stimulus effects of mirfentanil do not appear to be mediated exclusively through opioid receptors. Finally, mirfentanil does not appear to disrupt complex behavioral processes. Copyright (C) 1999 Elsevier Science Inc.
KW - Discriminative stimulus effects
KW - Fentanyl derivative
KW - Mirfentanil
KW - Rhesus monkey
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U2 - 10.1016/S0091-3057(99)00058-1
DO - 10.1016/S0091-3057(99)00058-1
M3 - Article
C2 - 10515315
AN - SCOPUS:0032822970
SN - 0091-3057
VL - 64
SP - 367
EP - 371
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 2
ER -