Effects of a highly purified antiserum to FSH on testicular function in immature rats

S. Sivashankar, M. R.N. Prasad, T. N.R.V. Thampan, C. S. Rani, N. R. Moudgal

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Effects of highly purified antiserum (AS) to follicle stimulating hormone (FSH) on testicular function was studied in immature rats. Treatment with FSHAS for 10 days, from 25-34, decreased weights of the testis (p .001) and increased weights of the epididymis (p .05). Numbers of the cell types in the seminiferous epithelium, particularly Type A spermatogonia pachytene spermatocytes and spermatids, were markedly reduced, possibly due to: 1) decreased division of the initial stem cells, 2) impairment of division of Type B spermatogonia and their transformation to pachytene spermatocytes, and 3) desquamation and degeneration of pachytene spermatocytes and spermatids. FSHAS also affected the sertoli cell function which was reflected in the decreased binding of androgens to supernatant fraction of the testis and epididymides. Treatment with luteinizing hormone-AS for 5 days did not affect testicular function but the binding of androgens to the supernatants of the caput and cauda epididymides and ventral prostate was significantly reduced (p .001). These data indicate that FSH is necessary for the maintenance of the cellular integrity of the seminiferous epithelium during the completion of the 1st wave of spermatogenesis.

Original languageEnglish (US)
Pages (from-to)845-851
Number of pages7
JournalIndian Journal of Experimental Biology
Volume15
Issue number10
StatePublished - Dec 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Effects of a highly purified antiserum to FSH on testicular function in immature rats'. Together they form a unique fingerprint.

Cite this