TY - JOUR
T1 - Effects of Δ9-tetrahydrocannabinol, (R)-methanandamide, SR 141716, and d-amphetamine before and during daily Δ9-tetrahydrocannabinol dosing
AU - Lamb, Richard J.
AU - Järbe, Torbjörn U.C.
AU - Makriyannis, Alexandros
AU - Lin, Sonyan
AU - Goutopoulos, Andreas
N1 - Funding Information:
We thank NIDA for the supplies of Δ9-THC and Sanofi Recherché, France, for the supplies of SR 141716 used in these experiments. We would also like to acknowledge the technical assistance of A. Dickstein and M. Harris. All procedures were approved by the Animal Care and Use Committee of Allegheny University of the Health Sciences. Preliminary results of this investigation were presented at the annual CPDD meeting, Nashville, TN, June 1997. Supported by NIDA grants DA 09064 and DA 00253 (Philadelphia), and DA 03801 and DA 00152 (Storrs).
PY - 2000/6/16
Y1 - 2000/6/16
N2 - We examined the effects of Δ9-tetrahydrocannabinol (Δ9-THC), (R)-(+)-arachidonyl-1'-hydroxy-2'-propylamide ((R)-methanandamide, AM 356), SR 141716, and d-amphetamine on fixed-ratio (FR) responding maintained by food in rats before and during daily dosing with Δ9-THC. Rats responded under a FR 10 schedule of food reinforcement. Cumulative dose-response curves for the various drugs were determined before and during daily Δ9-THC administration. All four drugs dose-dependently decreased responding both before and during daily dosing with Δ9-THC (18 mg/kg/day). The dose-response curves for both Δ9-THC and (R)-methanandamide were shifted to the right with daily dosing with Δ9-THC, indicating tolerance to the effects of Δ9-THC and cross-tolerance to the effects of (R)-methanandamide. The doses of d-amphetamine examined produced similar effects both before and during daily dosing with Δ9-THC. The effects of SR 141716 were not consistently altered by daily Δ9-THC administration. These results indicate that tolerance develops to the effects of Δ9-THC, when Δ9-THC is administered repeatedly. These results also indicate that cross-tolerance to (R)-methanandamide develops with repeated Δ9-THC administration. Copyright (C) 2000 Elsevier Science B.V.
AB - We examined the effects of Δ9-tetrahydrocannabinol (Δ9-THC), (R)-(+)-arachidonyl-1'-hydroxy-2'-propylamide ((R)-methanandamide, AM 356), SR 141716, and d-amphetamine on fixed-ratio (FR) responding maintained by food in rats before and during daily dosing with Δ9-THC. Rats responded under a FR 10 schedule of food reinforcement. Cumulative dose-response curves for the various drugs were determined before and during daily Δ9-THC administration. All four drugs dose-dependently decreased responding both before and during daily dosing with Δ9-THC (18 mg/kg/day). The dose-response curves for both Δ9-THC and (R)-methanandamide were shifted to the right with daily dosing with Δ9-THC, indicating tolerance to the effects of Δ9-THC and cross-tolerance to the effects of (R)-methanandamide. The doses of d-amphetamine examined produced similar effects both before and during daily dosing with Δ9-THC. The effects of SR 141716 were not consistently altered by daily Δ9-THC administration. These results indicate that tolerance develops to the effects of Δ9-THC, when Δ9-THC is administered repeatedly. These results also indicate that cross-tolerance to (R)-methanandamide develops with repeated Δ9-THC administration. Copyright (C) 2000 Elsevier Science B.V.
KW - (R)-Methanandamide
KW - Amphetamine
KW - Anandamide
KW - Cross-tolerance
KW - Dependence
KW - Operant behavior
KW - Rat
KW - SR 141716
KW - Tolerance
KW - Δ9-Tetrahydrocannabinol
UR - http://www.scopus.com/inward/record.url?scp=0343239120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0343239120&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(00)00318-6
DO - 10.1016/S0014-2999(00)00318-6
M3 - Article
C2 - 10854837
AN - SCOPUS:0343239120
VL - 398
SP - 251
EP - 258
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -