Effectiveness of Compounded Bioidentical Hormone Replacement Therapy: An Observational Cohort Study

Andres D. Ruiz, Kelly R. Daniels, Jamie C. Barner, John J. Carson, Chris Frei

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Bioidentical Hormone Replacement Therapy (BHRT) is believed it to be a safer and equally effective alternative to Conventional Hormone Therapy for the relief of menopausal symptoms; however, data are needed to support these claims. The objective of this study is to evaluate the effectiveness of compounded BHRT provided in six community pharmacies.Methods: This was an observational cohort study of women between the ages of 18-89 who received a compounded BHRT product from January 1, 2003 to April 30, 2010 in six community pharmacies. Data included patient demographics, comorbidities, therapeutic outcomes, and hormone therapies. Women self-rated menopausal symptoms as absent, mild, moderate, or severe. Descriptive statistics were used to characterize the patient population, BHRT use, and adverse events. Patient symptom severity was compared at baseline and 3 to 6 months follow-up using the Wilcoxon signed-rank test.Results: Women (n = 296) receiving BHRT at Oakdell Pharmacy had a mean (standard deviation) age of 52 (9) years. The most common BHRT dosage forms utilized were topical (71%) and oral (43%). Compounded BHRT regimens were generally initiated at low doses regardless of route. Women experienced a 25% decrease in emotional lability (p < 0.01), a 25% decrease in irritability (p < 0.01), and a 22% reduction in anxiety (p = 0.01) within 3 to 6 months. These women also experienced a 14% reduction in night sweats (p = 0.09) and a 6% reduction in hot flashes (p = 0.50).Conclusions: This study demonstrates that compounded BHRT improves mood symptoms. Larger studies are needed to examine the impact on vasomotor symptoms, myocardial infarction and breast cancer.

Original languageEnglish (US)
Article number27
JournalBMC Women's Health
Volume11
DOIs
StatePublished - Jul 8 2011

Fingerprint

Hormone Replacement Therapy
Observational Studies
Cohort Studies
Pharmacies
Hormones
Hot Flashes
Sweat
Dosage Forms
Nonparametric Statistics
Comorbidity
Therapeutics
Anxiety
Myocardial Infarction
Demography
Breast Neoplasms
Population

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Effectiveness of Compounded Bioidentical Hormone Replacement Therapy : An Observational Cohort Study. / Ruiz, Andres D.; Daniels, Kelly R.; Barner, Jamie C.; Carson, John J.; Frei, Chris.

In: BMC Women's Health, Vol. 11, 27, 08.07.2011.

Research output: Contribution to journalArticle

Ruiz, Andres D. ; Daniels, Kelly R. ; Barner, Jamie C. ; Carson, John J. ; Frei, Chris. / Effectiveness of Compounded Bioidentical Hormone Replacement Therapy : An Observational Cohort Study. In: BMC Women's Health. 2011 ; Vol. 11.
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