TY - JOUR
T1 - Effective separation of normal, acutely ischemic, and reperfused myocardium with P-31 MR spectrometry
AU - Rehr, R. B.
AU - Tatum, J. L.
AU - Hirsch, H. I.
AU - Wetstein, L.
AU - Clarke, G.
PY - 1988
Y1 - 1988
N2 - The ability of phosphorus-31 magnetic resonance (MR) spectrometry to accurately characterize myocardium as normal, ischemic, or reperfused but viable was examined in the canine model of acute coronary artery occlusion. P-31 MR measurements of in vivo myocardial pH, phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were made at baseline and for 6 hours after sustained coronary occlusion (ten animals) or coronary occlusion reperfused after 60 minutes (12 animals). Ten control animals were studied in parallel fashion, without coronary occlusion. Myocardial tissue characterization derived from the P-31 MR spectroscopy data by logistic regression analysis had an overall accuracy of 89%. Overall accuracy was unaffected by duration between coronary occlusion and P-31 MR study. Thus, metabolic data obtained with P-31 MR spectroscopy effectively separate normal, acutely ischemic, and reperfused but viable myocardium.
AB - The ability of phosphorus-31 magnetic resonance (MR) spectrometry to accurately characterize myocardium as normal, ischemic, or reperfused but viable was examined in the canine model of acute coronary artery occlusion. P-31 MR measurements of in vivo myocardial pH, phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were made at baseline and for 6 hours after sustained coronary occlusion (ten animals) or coronary occlusion reperfused after 60 minutes (12 animals). Ten control animals were studied in parallel fashion, without coronary occlusion. Myocardial tissue characterization derived from the P-31 MR spectroscopy data by logistic regression analysis had an overall accuracy of 89%. Overall accuracy was unaffected by duration between coronary occlusion and P-31 MR study. Thus, metabolic data obtained with P-31 MR spectroscopy effectively separate normal, acutely ischemic, and reperfused but viable myocardium.
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U2 - 10.1148/radiology.168.1.3380986
DO - 10.1148/radiology.168.1.3380986
M3 - Article
C2 - 3380986
AN - SCOPUS:0023883517
SN - 0033-8419
VL - 168
SP - 81
EP - 89
JO - Radiology
JF - Radiology
IS - 1
ER -