Effect with time of a norepinephrine synthesis inhibitor (U-14,624) on hypothalamic catecholamine and plasma gonadotrophin concentrations in the ovariectomized rat

S. R. Kohn, W. W. Morgan, A. J. Carrillo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Injection of the dopamine hydroxylase inhibitor U-14,624, to ovariectomized rats resulted in the reduction of hypothalamic norepinephrine concentration over a 48-h period and the elevation of hypothalamic dopamine concentration over a 24-h period. Plasma LH and FSH levels were markedly suppressed up to 48 h after drug treatment. These results suggest that U-14,624 is a much more potent inhibitor of gonadotropin secretion than has been previously reported.

Original languageEnglish (US)
Pages (from-to)184-188
Number of pages5
JournalJournal of reproduction and fertility
Volume66
Issue number1
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology

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