Effect of zinc deficiency on autologous rosette-forming cells

Leonard Nash, Tsutomu Iwata, Gabriel Fernandes, Robert A. Good, Geneviève S. Incefy

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Ability to form autologous rosettes (A-rosettes) is characteristic of a certain population of immature T cells, present in the thymus of various species including man. In mice, few A-rosettes are normally found in peripheral blood and spleen but their number increases markedly in spleen following thymectomy. In our studies, A-rosette formation could be demonstrated to be significantly enhanced in the spleen of C57B1/Ks mice after the animals had been maintained 3, 6, and 8 weeks on a zinc-deficient diet (Zn-) and to increase progressively with duration of feeding the Zn- diet. These changes were quickly reversed by feeding a normal diet containing zinc but could not be eliminated by complete adrenalectomy, a finding that ruled out their dependence on pituitary-adrenal as is function attributable to stress. Pair-fed controls and mice fed a zinc-supplemented diet ad libitum showed few A-rosettes, as expected.

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalCellular Immunology
Issue number1
StatePublished - Nov 1979

ASJC Scopus subject areas

  • Immunology


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