Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity

C. Dall'Asta, P. Vedani, P. Manunta, P. Pizzocri, M. Marchi, M. Paganelli, F. Folli, A. E. Pontiroli

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Background and aims: Several mechanisms are probably involved in obesity-related hypertension. This study was aimed to investigate the effect of significant weight loss on blood pressure and plasma renin activity (PRA) and aldosterone levels, other then on metabolic profile, in normotensive and hypertensive obese subjects. Methods and results: Forty hypertensive and 55 normotensive obese subjects were studied under basal conditions and again 1 year after significant weight loss obtained through laparoscopic adjustable gastric banding (LAGB). Weight, waist circumference, blood glucose, insulin, electrolytes (Na and K), lipids and supine and upright PRA and aldosterone were evaluated. All parameters evaluated improved, except for total cholesterol, and electrolytes that did not change. Blood pressure decreased in hypertensive subjects, with a concordant decrease in PRA and supine aldosterone levels, not observed in normotensive patients. Conclusion: Weight loss is associated with reduction of blood pressure and of PRA and aldosterone levels in obese hypertensive subjects.

Original languageEnglish (US)
Pages (from-to)110-114
Number of pages5
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume19
Issue number2
DOIs
StatePublished - Feb 1 2009

Keywords

  • Aldosterone
  • Arterial hypertension
  • Bariatric surgery
  • Obesity
  • Renin
  • Weight loss

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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