Effect of weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluurene-induced mutation in Salmonella typhimurium

C. E. Weeks; T. K. Rao; J. A. Young; T. J. Slaga; J. L. Epler

doi:10.1016/0300-483X(79)90007-6

Effect of weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluurene-induced mutation in Salmonella typhimurium

C. E. Weeks, T. K. Rao, J. A. Young, T. J. Slaga, J. L. Epler

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effects of various weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluorene-induced mutation in Salmonella typhimurium were studied. We found that a single co-mutagen could provide for either enhanced or decreased mutagenesis. A differential effect on mutagenic expression was dependent upon: (1) the type of inducer of S-9 (supernatant from liver homogenate centrifuged at 9000 × g) liver enzymes; (2) the amount of S-9 enzyme preparation employed; and (3) the combined dose of mutagen plus co-mutagen studied. No effect was observed in the absence of S-9. Our data suggest that in S. typhimurium a primary factor in the alteration of mutagenesis by a combination of chemicals is changes in metabolism of the principal mutagen.

Original language	English (US)
Pages (from-to)	255-262
Number of pages	8
Journal	Toxicology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0300-483X(79)90007-6
State	Published - Nov 1979
Externally published	Yes

ASJC Scopus subject areas

Toxicology

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@article{486493433983421e87e9741619049b27,

title = "Effect of weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluurene-induced mutation in Salmonella typhimurium",

abstract = "The effects of various weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluorene-induced mutation in Salmonella typhimurium were studied. We found that a single co-mutagen could provide for either enhanced or decreased mutagenesis. A differential effect on mutagenic expression was dependent upon: (1) the type of inducer of S-9 (supernatant from liver homogenate centrifuged at 9000 × g) liver enzymes; (2) the amount of S-9 enzyme preparation employed; and (3) the combined dose of mutagen plus co-mutagen studied. No effect was observed in the absence of S-9. Our data suggest that in S. typhimurium a primary factor in the alteration of mutagenesis by a combination of chemicals is changes in metabolism of the principal mutagen.",

author = "Weeks, {C. E.} and Rao, {T. K.} and Young, {J. A.} and Slaga, {T. J.} and Epler, {J. L.}",

note = "Funding Information: *Research sponsored by the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation. Abbreviations: AAF, 2-acetyla:~inofluorene; At, Aroclor 1254; BaP, benzo\[a\]pyrene; BeP, benzo\[e\ ]pyrene; MC, 3-methylcholanthrene; PAH, polycyclic aromatic hydrocarbon ; PB, phenobarbital; P, pyrene; S-9, supernatant from liver homogenate centrifuged at 9000 x g; TPA, 12-O-tetradecanoylphorbol-13-acetate.",

year = "1979",

month = nov,

doi = "10.1016/0300-483X(79)90007-6",

language = "English (US)",

volume = "14",

pages = "255--262",

journal = "Toxicology",

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publisher = "Elsevier Ireland Ltd",

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T1 - Effect of weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluurene-induced mutation in Salmonella typhimurium

AU - Weeks, C. E.

AU - Rao, T. K.

AU - Young, J. A.

AU - Slaga, T. J.

AU - Epler, J. L.

N1 - Funding Information: *Research sponsored by the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation. Abbreviations: AAF, 2-acetyla:~inofluorene; At, Aroclor 1254; BaP, benzo\[a\]pyrene; BeP, benzo\[e\ ]pyrene; MC, 3-methylcholanthrene; PAH, polycyclic aromatic hydrocarbon ; PB, phenobarbital; P, pyrene; S-9, supernatant from liver homogenate centrifuged at 9000 x g; TPA, 12-O-tetradecanoylphorbol-13-acetate.

PY - 1979/11

Y1 - 1979/11

N2 - The effects of various weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluorene-induced mutation in Salmonella typhimurium were studied. We found that a single co-mutagen could provide for either enhanced or decreased mutagenesis. A differential effect on mutagenic expression was dependent upon: (1) the type of inducer of S-9 (supernatant from liver homogenate centrifuged at 9000 × g) liver enzymes; (2) the amount of S-9 enzyme preparation employed; and (3) the combined dose of mutagen plus co-mutagen studied. No effect was observed in the absence of S-9. Our data suggest that in S. typhimurium a primary factor in the alteration of mutagenesis by a combination of chemicals is changes in metabolism of the principal mutagen.

AB - The effects of various weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluorene-induced mutation in Salmonella typhimurium were studied. We found that a single co-mutagen could provide for either enhanced or decreased mutagenesis. A differential effect on mutagenic expression was dependent upon: (1) the type of inducer of S-9 (supernatant from liver homogenate centrifuged at 9000 × g) liver enzymes; (2) the amount of S-9 enzyme preparation employed; and (3) the combined dose of mutagen plus co-mutagen studied. No effect was observed in the absence of S-9. Our data suggest that in S. typhimurium a primary factor in the alteration of mutagenesis by a combination of chemicals is changes in metabolism of the principal mutagen.

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Effect of weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluurene-induced mutation in Salmonella typhimurium

Abstract

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