Effect of weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluurene-induced mutation in Salmonella typhimurium

C. E. Weeks, T. K. Rao, J. A. Young, T. J. Slaga, J. L. Epler

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The effects of various weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluorene-induced mutation in Salmonella typhimurium were studied. We found that a single co-mutagen could provide for either enhanced or decreased mutagenesis. A differential effect on mutagenic expression was dependent upon: (1) the type of inducer of S-9 (supernatant from liver homogenate centrifuged at 9000 × g) liver enzymes; (2) the amount of S-9 enzyme preparation employed; and (3) the combined dose of mutagen plus co-mutagen studied. No effect was observed in the absence of S-9. Our data suggest that in S. typhimurium a primary factor in the alteration of mutagenesis by a combination of chemicals is changes in metabolism of the principal mutagen.

Original languageEnglish (US)
Pages (from-to)255-262
Number of pages8
JournalToxicology
Volume14
Issue number3
DOIs
StatePublished - Nov 1979
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Effect of weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluurene-induced mutation in Salmonella typhimurium'. Together they form a unique fingerprint.

  • Cite this