Effect of ventriculo cisternal perfusion with angiotensin II and indomethacin on the plasma vasopressin concentration

M. Yamamoto, L. Share, R. E. Shade

    Research output: Contribution to journalArticle

    27 Scopus citations

    Abstract

    In anesthetized dogs, perfusion of the cerebral ventricles with indomethacin (IM), an inhibitor of prostaglandin biosynthesis, at rates of 1.9 or 7.6 μg/min was without effect on the plasma ADH concentration. Ventriculo-cisternal perfusion with angiotensin II (AII; 19 ng/min) resulted in a 3-fold increase in the plasma ADH concentration within 45 min. When AII and IM were perfused together, the plasma ADH concentration increased only 2-fold, a response which was significantly lower than that obtained with AII alone. Thus, the ability of central AII to stimulate ADH release may depend, at least in part, upon the local release of prostaglandins.

    Original languageEnglish (US)
    Pages (from-to)166-173
    Number of pages8
    JournalNeuroendocrinology
    Volume25
    Issue number3
    DOIs
    StatePublished - Jan 1 1978

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Endocrine and Autonomic Systems
    • Cellular and Molecular Neuroscience

    Fingerprint Dive into the research topics of 'Effect of ventriculo cisternal perfusion with angiotensin II and indomethacin on the plasma vasopressin concentration'. Together they form a unique fingerprint.

  • Cite this