Effect of tunicamycin on receptors for tumor promoters

V. Solanki, M. K. Logani, Thomas J Slaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A progressive decline in the specific binding of [20-3H]phorbol 12,13-dibutyrate ([3H]PDBu) and glycoprotein synthesis was observed following treatment of primary mouse epidermal cells with tunicamycin, a specific inhibitor of dolichol-mediated glycosylation. Following 18 h of treatment, the specific binding of [3H]PDBu was reduced to 33-56% of the control value. The total protein synthesis determined by leucine incorporation into acid-insoluble material was not altered by this antibiotic drug. These results suggest that the receptor for phorbol diesters is, or is functionally linked to, a glycoprotein on the cell surface.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalCancer Letters
Volume16
Issue number3
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Dolichol
Phorbol 12,13-Dibutyrate
Tunicamycin
Membrane Glycoproteins
Phorbol Esters
Glycosylation
Leucine
Carcinogens
Glycoproteins
Anti-Bacterial Agents
Acids
Pharmaceutical Preparations
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Effect of tunicamycin on receptors for tumor promoters. / Solanki, V.; Logani, M. K.; Slaga, Thomas J.

In: Cancer Letters, Vol. 16, No. 3, 1982, p. 319-325.

Research output: Contribution to journalArticle

Solanki, V. ; Logani, M. K. ; Slaga, Thomas J. / Effect of tunicamycin on receptors for tumor promoters. In: Cancer Letters. 1982 ; Vol. 16, No. 3. pp. 319-325.
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