Effect of tunicamycin on receptors for tumor promoters

V. Solanki, M. K. Logani, T. J. Slaga

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A progressive decline in the specific binding of [20-3H]phorbol 12,13-dibutyrate ([3H]PDBu) and glycoprotein synthesis was observed following treatment of primary mouse epidermal cells with tunicamycin, a specific inhibitor of dolichol-mediated glycosylation. Following 18 h of treatment, the specific binding of [3H]PDBu was reduced to 33-56% of the control value. The total protein synthesis determined by leucine incorporation into acid-insoluble material was not altered by this antibiotic drug. These results suggest that the receptor for phorbol diesters is, or is functionally linked to, a glycoprotein on the cell surface.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalCancer Letters
Volume16
Issue number3
DOIs
StatePublished - Sep 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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