Effect of tocolytic agents on fetal umbilical velocimetry

Jeffrey W. Wright, Robert M. Patterson, Louis E. Ridgway, Michael D. Berkus

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


In this prospective study, we sought to examine the changes in umbilical vascular resistance induced by tocolytic therapy. Umbilical artery velocimetry was performed in 46 patients with preterm labor before tocolysis and at 1 hour and 24 hours after tocolysis was initiated. Raw systolic/diastolic ratios were corrected for concomitant changes in fetal heart rate. Thirty patients received subcutaneous terbutaline and 16 were treated with intravenous magnesium. Systolic/diastolic ratios decreased in patients treated with terbutaline. This decline persisted after correction for increases in fetal heart rate. No significant changes in systolic/diastolic ratios were seen in patients treated with magnesium. We conclude that terbutaline may affect umbilical vascular resistance. Possible clinical implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)748-750
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Issue number3
StatePublished - Sep 1990


  • Doppler
  • Tocolytic
  • magnesium
  • terbutaline
  • umbilical velocimetry

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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