Effect of thiol modification on the thermal stability of erythrocyte membranes

Z. Jóźwiak, M. Gaczynska, M. Soszynski

Research output: Contribution to journalArticlepeer-review


1. 1.|The effect of chemical modification of membrane proteins on the heat response of erythrocytes has been studied. 2. 2.|Erythrocytes preincubated with N-ethylmaleimide (NEM) or p-chloromercuribenzoic acid (pCMB), followed by heating at temperatures above 44°C, indicated a decreased thermal stability. 3. 3.|The action of pCMB is much more toxic to erythrocytes than the effect of NEM. 4. 4.|These results suggest that modification of proteins by SH reagents could be responsible for changes in the structural integrity of pig erythrocyte plasma membrane leading to their reduced thermal stability.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalJournal of Thermal Biology
Issue number2
StatePublished - Apr 1994
Externally publishedYes


  • Erythrocytes
  • SH reagents
  • heat
  • membrane proteins
  • thermal stability

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Agricultural and Biological Sciences(all)
  • Developmental Biology


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