Abstract
1. 1.|The effect of chemical modification of membrane proteins on the heat response of erythrocytes has been studied. 2. 2.|Erythrocytes preincubated with N-ethylmaleimide (NEM) or p-chloromercuribenzoic acid (pCMB), followed by heating at temperatures above 44°C, indicated a decreased thermal stability. 3. 3.|The action of pCMB is much more toxic to erythrocytes than the effect of NEM. 4. 4.|These results suggest that modification of proteins by SH reagents could be responsible for changes in the structural integrity of pig erythrocyte plasma membrane leading to their reduced thermal stability.
Original language | English (US) |
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Pages (from-to) | 141-147 |
Number of pages | 7 |
Journal | Journal of Thermal Biology |
Volume | 19 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1994 |
Externally published | Yes |
Keywords
- Erythrocytes
- SH reagents
- heat
- membrane proteins
- thermal stability
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Agricultural and Biological Sciences(all)
- Developmental Biology