Effect of the treatment with methylprednisolone on the cerebrospinal fluid and serum levels of CCL2 and CXCL10 chemokines in patients with active multiple sclerosis

M. A. Moreira, C. P. Tilbery, L. P. Monteiro, M. M. Teixeira, A. L. Teixeira

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Background - Several experimental and human studies suggest that the chemokines CCL2 and CXCL10 may play a role in the pathogenesis of multiple sclerosis (MS). Here, we evaluated the effect of intravenous methylprednisolone (IVMP) therapy on the levels of CCL2 and CXCL10 in the cerebrospinal fluid (CSF) and serum of patients with active MS. Methods - Serum and CSF samples were obtained from 14 patients with active relapsing-remitting MS (age ± SD years, 37.0 ± 8.1; M/F, 6/8) and age- and gender-matched control subjects. All patients were submitted to IVMP treatment (500 mg daily for 5 days). Blood and CSF sampling were performed at admission, i.e. before treatment (day 0), at the end of the treatment (day 6) and 30 days after treatment (day 30). The clinical status of MS patients was also assessed. CCL2 and CXCL10 were measured by enzyme-linked immunosorbent assay. Results - Multiple sclerosis patients had lower CCL2 and higher CXCL10 in CSF when compared with control subjetcs. After treatment with methylprednisolone, MS patients showed clinical improvement and the CSF concentrations of CCL2 and CXCL10 modified toward normal values. Conclusions - The clinical improvement of active MS following the treatment with methylprednisolone was associated with the modification of CSF levels of CCL2 and CXCL10, suggesting that these chemokines may be useful markers of response to treatment and relapses in MS patients.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalActa Neurologica Scandinavica
Volume114
Issue number2
DOIs
StatePublished - Aug 2006
Externally publishedYes

Keywords

  • CCL2
  • Chemokines
  • Corticosteroids
  • CXCL10
  • Methylprednisolone
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Effect of the treatment with methylprednisolone on the cerebrospinal fluid and serum levels of CCL2 and CXCL10 chemokines in patients with active multiple sclerosis'. Together they form a unique fingerprint.

Cite this