Abstract
Athymic nude mouse homozygotes (nu/nu) and the heterozygote nu/nu+ were injected intraperitoneally with 2 mg of cyclosporin-A (CS-A) twice, 72 and 1 h prior to analysis. We have found that in vivo administration of CS-A results in a significant suppression of natural killer (NK) cell and antibody-dependent cell-mediated cytotoxic (ADCC) activity which probably play an important role in tumor and graft rejection. T cells were also suppressed, in contrast, B cells were found to be immunocompetent as determined by cell proliferation and antibody-forming capacity in response to mitogens and antigens. The identity of cells mediating NK cell and ADCC activity and its relationship to T lymphocytes are also discussed.
Original language | English (US) |
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Pages (from-to) | 465-469 |
Number of pages | 5 |
Journal | International Archives of Allergy and Immunology |
Volume | 65 |
Issue number | 4 |
DOIs | |
State | Published - 1981 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology