Effect of the new immunosuppressive agent, cyclosporin-a, on natural killer cell and antibody-dependent cell-mediated cytotoxic activity

A. M. Attallah, A. Urritia-Shaw, T. J. Yeatman, T. Folks

    Research output: Contribution to journalArticle

    10 Scopus citations

    Abstract

    Athymic nude mouse homozygotes (nu/nu) and the heterozygote nu/nu+ were injected intraperitoneally with 2 mg of cyclosporin-A (CS-A) twice, 72 and 1 h prior to analysis. We have found that in vivo administration of CS-A results in a significant suppression of natural killer (NK) cell and antibody-dependent cell-mediated cytotoxic (ADCC) activity which probably play an important role in tumor and graft rejection. T cells were also suppressed, in contrast, B cells were found to be immunocompetent as determined by cell proliferation and antibody-forming capacity in response to mitogens and antigens. The identity of cells mediating NK cell and ADCC activity and its relationship to T lymphocytes are also discussed.

    Original languageEnglish (US)
    Pages (from-to)465-469
    Number of pages5
    JournalInternational Archives of Allergy and Immunology
    Volume65
    Issue number4
    DOIs
    StatePublished - Jan 1 1981

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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