Abstract
Athymic nude mouse homozygotes (nu/nu) and the heterozygote nu/nu+ were injected intraperitoneally with 2 mg of cyclosporin-A (CS-A) twice, 72 and 1 h prior to analysis. We have found that in vivo administration of CS-A results in a significant suppression of natural killer (NK) cell and antibody-dependent cell-mediated cytotoxic (ADCC) activity which probably play an important role in tumor and graft rejection. T cells were also suppressed, in contrast, B cells were found to be immunocompetent as determined by cell proliferation and antibody-forming capacity in response to mitogens and antigens. The identity of cells mediating NK cell and ADCC activity and its relationship to T lymphocytes are also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 465-469 |
| Number of pages | 5 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 65 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1981 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Attallah, A. M., Urritia-Shaw, A., Yeatman, T. J., & Folks, T. (1981). Effect of the new immunosuppressive agent, cyclosporin-a, on natural killer cell and antibody-dependent cell-mediated cytotoxic activity. International Archives of Allergy and Immunology, 65(4), 465-469. https://doi.org/10.1159/000232789