Effect of the new immunosuppressive agent, cyclosporin-a, on natural killer cell and antibody-dependent cell-mediated cytotoxic activity

A. M. Attallah; A. Urritia-Shaw; T. J. Yeatman; T. Folks

doi:10.1159/000232789

Effect of the new immunosuppressive agent, cyclosporin-a, on natural killer cell and antibody-dependent cell-mediated cytotoxic activity

A. M. Attallah, A. Urritia-Shaw, T. J. Yeatman, T. Folks

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Abstract

Athymic nude mouse homozygotes (nu/nu) and the heterozygote nu/nu⁺ were injected intraperitoneally with 2 mg of cyclosporin-A (CS-A) twice, 72 and 1 h prior to analysis. We have found that in vivo administration of CS-A results in a significant suppression of natural killer (NK) cell and antibody-dependent cell-mediated cytotoxic (ADCC) activity which probably play an important role in tumor and graft rejection. T cells were also suppressed, in contrast, B cells were found to be immunocompetent as determined by cell proliferation and antibody-forming capacity in response to mitogens and antigens. The identity of cells mediating NK cell and ADCC activity and its relationship to T lymphocytes are also discussed.

Original language	English (US)
Pages (from-to)	465-469
Number of pages	5
Journal	International Archives of Allergy and Immunology
Volume	65
Issue number	4
DOIs	https://doi.org/10.1159/000232789
State	Published - 1981

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Effect of the new immunosuppressive agent, cyclosporin-a, on natural killer cell and antibody-dependent cell-mediated cytotoxic activity",

abstract = "Athymic nude mouse homozygotes (nu/nu) and the heterozygote nu/nu+ were injected intraperitoneally with 2 mg of cyclosporin-A (CS-A) twice, 72 and 1 h prior to analysis. We have found that in vivo administration of CS-A results in a significant suppression of natural killer (NK) cell and antibody-dependent cell-mediated cytotoxic (ADCC) activity which probably play an important role in tumor and graft rejection. T cells were also suppressed, in contrast, B cells were found to be immunocompetent as determined by cell proliferation and antibody-forming capacity in response to mitogens and antigens. The identity of cells mediating NK cell and ADCC activity and its relationship to T lymphocytes are also discussed.",

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AU - Yeatman, T. J.

AU - Folks, T.

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AB - Athymic nude mouse homozygotes (nu/nu) and the heterozygote nu/nu+ were injected intraperitoneally with 2 mg of cyclosporin-A (CS-A) twice, 72 and 1 h prior to analysis. We have found that in vivo administration of CS-A results in a significant suppression of natural killer (NK) cell and antibody-dependent cell-mediated cytotoxic (ADCC) activity which probably play an important role in tumor and graft rejection. T cells were also suppressed, in contrast, B cells were found to be immunocompetent as determined by cell proliferation and antibody-forming capacity in response to mitogens and antigens. The identity of cells mediating NK cell and ADCC activity and its relationship to T lymphocytes are also discussed.

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Effect of the new immunosuppressive agent, cyclosporin-a, on natural killer cell and antibody-dependent cell-mediated cytotoxic activity

Abstract

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