Effect of synthetic thyrotrophin releasing hormone on thyrotrophin and prolactin concentrations in the peripheral plasma of the pregnant ewe, lamb fetus and neonatal lamb

A. L. Thomas, P. M.B. Jack, J. G. Manns, P. W. Nathanielsz

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Synthetic thyrotrophin releasing hormone (TRH) has been administered to pregnant ewes, chronically catheterised fetuses in the latter stages of gestation, and to newborn lambs. Both the pregnant ewe and her fetus showed marked rises in TSH and prolactin concentrations after administration of TRH. The placenta was impermeable to TRH, TSH and prolactin in both directions. The sheep fetus near term and the newborn lamb both demonstrated a considerable reserve of secretory capacity for TSH and prolactin.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalBiology of the Neonate - Foetal and Neonatal Research
Volume26
Issue number1-2
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Fingerprint Dive into the research topics of 'Effect of synthetic thyrotrophin releasing hormone on thyrotrophin and prolactin concentrations in the peripheral plasma of the pregnant ewe, lamb fetus and neonatal lamb'. Together they form a unique fingerprint.

Cite this