Effect of stent surface-scattering properties on the appearance of stent struts in IV-OCT images was examined by simulation of light-stent interaction by an optical design software package. A phantom blood vessel was constructed from a mix of polydimethylsiloxane (PDMS) and titanium dioxide to simulate the elastic and optical scattering properties of the arterial wall. A Cordis CYPHER® sirolimus-eluting stent was deployed within the phantom vessel and high resolution Micro-CT images of the stent strut were recorded to create a three-dimensional representation that was imported into software. A Gaussian surface-scattering model (bi-directional scattering distribution function) was assumed for the strut. Simulation of IV-OCT catheter and reflection of light from the stent strut was implemented for different surface scattering properties. A model of IV-OCT catheter was defined in the optical model and the rotation of the light beam over the stent strut was simulated. The measured parameters included: fraction of the reflected rays returning to the catheter and coordinate locations on the stent struts of returned rays. The results indicate that when the surface scattering of the strut increases, reflectivity is higher, while the angular spread of the light beam that is reflected back to the catheter is wider.