Effect of spironolactone on androgen-dependent proteins in the ventral prostate of the rat

D. B. Carter, A. B. Silverberg, S. E. Harris

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The effect of spironolactone on five androgen-dependent proteins in the ventral prostate of the rat was investigated by two-dimensional gel electrophoresis. Spironolactone was given to intact male, castrated and androgen-stimulated castrated rats. It has been shown that spironolactone had no influence on the synthesis or accumulation of the androgen-dependent proteins in intact animals. However, spironolactone suppressed the restoration of the major androgen-dependent protein of low molecular weight in castrated rats given testosterone. The mechanism by which spironolactone exerts its anti-androgenic activity was shown to be unrelated to its capacity to inhibit the synthesis or accumulation of the five androgen-dependent proteins studied in this investigation.

Original languageEnglish (US)
Pages (from-to)471-476
Number of pages6
JournalJournal of Endocrinology
Volume86
Issue number3
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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