Effect of several androgens, cyproterone acetate or estrogen-progesterone on the prolactin-releasing activity of arginine vasotocin in castrated male rats

Mary K. Vaughan, David E. Blask, Linda Y. Johnson, Chatchai Trakulrungsi, Russel J. Reiter

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Intravenous (iv) administration of 5 μg of arginine vasotocin (AVT) into urethane-anesthetized, castrated male rats had no effect on plasma prolactin titers as compared to the rise in prolactin levels observed in intact AVT-treated rats. However, when castrated rats were first treated for two days with 2.5 mg/day of testosterone propionate and then challenged with a 5-μg dose of AVT, the prolactin surge values obtained were comparable to those seen in intact AVT-treated rats. Conversely, treatment of intact rats for two days with 25 mg/day of the antiandrogen, cyproterone acetate, blocked the prolactin-releasing activity of AVT. In a separate experiment, treatment of castrated rats for two days with 2.5 mg/day of testosterone androsterone or 50 μg of estradiol benzoate and 25 mg progesterone, completely restored the prolactin-releasing activity of AVT. Similar treatment with 2.5 mg/day of androstenedione or dihydrotestosterone was without effect in restoring this response to AVT. It is concluded that the presence of gonadal steroids is essential to the action of AVT in provoking the release of prolactin in urethane-anesthetized male rats.

Original languageEnglish (US)
Pages (from-to)309-318
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume12
Issue number3
DOIs
StatePublished - Dec 1978

Keywords

  • androstenedione
  • androsterone
  • arginine vasotocin
  • castration
  • cyproterone acetate
  • dihydrotestosterone
  • prolactin
  • testosterone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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