Effect of protaglandin E in multiple experimental models. VI. Effects on T-cell subsets

J. P. Waymack, R. F. Guzman, D. G. Burleson, A. T. McManus, A. D. Mason, B. A. Pruitt

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Burn injuries have been showing to impair immune function. One of the hypotheses for the etiology of the immunosuppression is that burn injuries result in an elevation of prostaglandin E (PGE) levels which then impair leukocyte fuction. We evaluated the effect of PGE levels on immune function in multiple animal models utilizing T cell subset levels for our immunologic measurements. Elevations in PGE levels were achieved by adminsgtering 16,16-dimethyl-prostoglandin E (dPGE) and reductions by administering indomethacin. The animal models included burned rats, burned-septic rats, and nonburned rats. Neither indomethacin nor dPGE administration resulted in alterations of any of the T cell subset populations in our models.

Original languageEnglish (US)
Pages (from-to)345-353
Number of pages9
JournalProstaglandins
Volume38
Issue number3
DOIs
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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