Effect of prostaglandin inhibition on the renal vascular response to ionic and non-ionic contrast media in the dog

G. Lund, S. Einzig, J. Rysavy, E. Salomonowitz, W. Castaneda-Zuniga, K. Amplatz

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

In an attempt to study the role of prostaglandins in the renal vascular response to contrast media in mongrel dogs, renal arterial injections of 6 ml of either the non-ionic contrast medium Iopamidol or the ionic medium diatrizoate meglumine/Na+ were performed, before and after intravenous injection of a buffered solution of acetylsalicylic acid (10 mg/kg) (ASA). Renal blood flow was recorded using non-occluding electromagnetic flow probes. The resting renal blood flow was significantly reduced after ASA. The usual biphasic response to contrast injection was observed both before and after ASA, and using either contrast medium. Analysis of the results failed to show any difference in degree of vasodilation or vasoconstriction after ASA. We conclude that prostaglandins may affect the resting level of renal blood flow but are not mediators of the instantaneous changes in response to contrast injection.

Original languageEnglish (US)
Pages (from-to)407-410
Number of pages4
JournalActa Radiologica
Volume25
Issue number5
DOIs
StatePublished - Sep 1984

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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    Lund, G., Einzig, S., Rysavy, J., Salomonowitz, E., Castaneda-Zuniga, W., & Amplatz, K. (1984). Effect of prostaglandin inhibition on the renal vascular response to ionic and non-ionic contrast media in the dog. Acta Radiologica, 25(5), 407-410. https://doi.org/10.1177/028418518402500511