Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis

J. P. Waymack; R. F. Guzman; A. D. Mason; B. A. Pruitt

doi:10.1016/0305-4179(90)90198-6

Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis

J. P. Waymack, R. F. Guzman, A. D. Mason, B. A. Pruitt

Department of Surgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 10⁸ Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 10⁸, 1 × 10⁹ or 1 × 10¹⁰ Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	Burns
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/0305-4179(90)90198-6
State	Published - Feb 1990

ASJC Scopus subject areas

Surgery
Emergency Medicine
Critical Care and Intensive Care Medicine

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title = "Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis",

abstract = "The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 108 Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 108, 1 × 109 or 1 × 1010 Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.",

author = "Waymack, {J. P.} and Guzman, {R. F.} and Mason, {A. D.} and Pruitt, {B. A.}",

note = "Funding Information: the ISBI. The funds do not overlap or mingle in any way with those of the ISBI. The only role the ISBI plays in the Tanner-Vandeput Prize is to coordinate and award the Prize for each Quadrennial Congress. The International Bum Foundation has a Board of Directors and a Prize Committee which reviews applications and makes recommendations for award of each Prize. The Prize Committee voted to award the first Tanner-Vandeput Prize, presented at the 7th International Congress held February 1986 in Melbourne, Australia to Dr Ian Alan Holder of the Shriners Burns Institute in Cincinnati, Ohio for his work on {\textquoteleft}Infection by Pseudomonas Aeruginosa.{\textquoteright} He was presented with a cash payment and a gold and diamond lapel pin signifying his achievement.",

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N1 - Funding Information: the ISBI. The funds do not overlap or mingle in any way with those of the ISBI. The only role the ISBI plays in the Tanner-Vandeput Prize is to coordinate and award the Prize for each Quadrennial Congress. The International Bum Foundation has a Board of Directors and a Prize Committee which reviews applications and makes recommendations for award of each Prize. The Prize Committee voted to award the first Tanner-Vandeput Prize, presented at the 7th International Congress held February 1986 in Melbourne, Australia to Dr Ian Alan Holder of the Shriners Burns Institute in Cincinnati, Ohio for his work on ‘Infection by Pseudomonas Aeruginosa.’ He was presented with a cash payment and a gold and diamond lapel pin signifying his achievement.

PY - 1990/2

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N2 - The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 108 Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 108, 1 × 109 or 1 × 1010 Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.

AB - The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 108 Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 108, 1 × 109 or 1 × 1010 Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.

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Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis

Abstract

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