Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis

J. P. Waymack, R. F. Guzman, A. D. Mason, B. A. Pruitt

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 108 Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 108, 1 × 109 or 1 × 1010 Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalBurns
Volume16
Issue number1
DOIs
StatePublished - Feb 1990

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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