Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis

J. P. Waymack; R. F. Guzman; A. D. Mason; B. A. Pruitt

doi:10.1016/0305-4179(90)90198-6

Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis

J. P. Waymack, R. F. Guzman, A. D. Mason, B. A. Pruitt

Surgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 10⁸ Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 10⁸, 1 × 10⁹ or 1 × 10¹⁰ Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	Burns
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/0305-4179(90)90198-6
State	Published - Feb 1990

ASJC Scopus subject areas

Surgery
Emergency Medicine
Critical Care and Intensive Care Medicine

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title = "Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis",

abstract = "The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 108 Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 108, 1 × 109 or 1 × 1010 Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.",

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AB - The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 108 Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 108, 1 × 109 or 1 × 1010 Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.

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