Effect of prostaglandin E in multiple experimental models. IV. Effect on resistance to endotoxin and tumor necrosis factor shock

J. Paul Waymack, Lyle L. Moldawer, Stephen F. Lowry, Rey F. Guzman, Carlin V. Okerberg, Arthur D. Mason, Basil A Pruitt

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Administration of a long-acting prostaglandin E, 16,16-dimethyl-PGE (dPGE), to rats improves their survival of bacterial peritonitis. We examined the mechanism of this protective effect with reference to its interaction with the release of cachectin (TNF). Sixty rats received saline, 20 μg/kg dPGE, or 80 μg/kg dPGE 12 hr prior to endotoxin and continuing for 48 hr. Survival rates for the saline, 20 μg/kg dPGE, and 80 μg/kg dPGE groups were 0, 40, and 85%, respectively. Forty rats received saline or 80 μg/kg dPGE, with the initial dose being 3 hr following endotoxin challenge and continuing for 48 hr. Survival rates for both groups were 0%. Sixty rats received saline or 80 μg/kg dPGE at 12 and 1 hr prior to endotoxin. Two hours after challenge, they were sacrificed and plasma TNF levels were assayed. The plasma TNF level in saline-treated rats was 22.72 ± 0.83 ng/ml and in the dPGE-treated group, 16.03 ± 1.13 ng/ml (P < 0.001).

Original languageEnglish (US)
Pages (from-to)328-332
Number of pages5
JournalJournal of Surgical Research
Volume49
Issue number4
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Prostaglandins E
Endotoxins
Shock
Theoretical Models
Tumor Necrosis Factor-alpha
Peritonitis

ASJC Scopus subject areas

  • Surgery

Cite this

Waymack, J. P., Moldawer, L. L., Lowry, S. F., Guzman, R. F., Okerberg, C. V., Mason, A. D., & Pruitt, B. A. (1990). Effect of prostaglandin E in multiple experimental models. IV. Effect on resistance to endotoxin and tumor necrosis factor shock. Journal of Surgical Research, 49(4), 328-332. https://doi.org/10.1016/0022-4804(90)90031-V

Effect of prostaglandin E in multiple experimental models. IV. Effect on resistance to endotoxin and tumor necrosis factor shock. / Waymack, J. Paul; Moldawer, Lyle L.; Lowry, Stephen F.; Guzman, Rey F.; Okerberg, Carlin V.; Mason, Arthur D.; Pruitt, Basil A.

In: Journal of Surgical Research, Vol. 49, No. 4, 1990, p. 328-332.

Research output: Contribution to journalArticle

Waymack, J. Paul ; Moldawer, Lyle L. ; Lowry, Stephen F. ; Guzman, Rey F. ; Okerberg, Carlin V. ; Mason, Arthur D. ; Pruitt, Basil A. / Effect of prostaglandin E in multiple experimental models. IV. Effect on resistance to endotoxin and tumor necrosis factor shock. In: Journal of Surgical Research. 1990 ; Vol. 49, No. 4. pp. 328-332.
@article{6fd1bc19bd7e4329823a72345707b601,
title = "Effect of prostaglandin E in multiple experimental models. IV. Effect on resistance to endotoxin and tumor necrosis factor shock",
abstract = "Administration of a long-acting prostaglandin E, 16,16-dimethyl-PGE (dPGE), to rats improves their survival of bacterial peritonitis. We examined the mechanism of this protective effect with reference to its interaction with the release of cachectin (TNF). Sixty rats received saline, 20 μg/kg dPGE, or 80 μg/kg dPGE 12 hr prior to endotoxin and continuing for 48 hr. Survival rates for the saline, 20 μg/kg dPGE, and 80 μg/kg dPGE groups were 0, 40, and 85{\%}, respectively. Forty rats received saline or 80 μg/kg dPGE, with the initial dose being 3 hr following endotoxin challenge and continuing for 48 hr. Survival rates for both groups were 0{\%}. Sixty rats received saline or 80 μg/kg dPGE at 12 and 1 hr prior to endotoxin. Two hours after challenge, they were sacrificed and plasma TNF levels were assayed. The plasma TNF level in saline-treated rats was 22.72 ± 0.83 ng/ml and in the dPGE-treated group, 16.03 ± 1.13 ng/ml (P < 0.001).",
author = "Waymack, {J. Paul} and Moldawer, {Lyle L.} and Lowry, {Stephen F.} and Guzman, {Rey F.} and Okerberg, {Carlin V.} and Mason, {Arthur D.} and Pruitt, {Basil A}",
year = "1990",
doi = "10.1016/0022-4804(90)90031-V",
language = "English (US)",
volume = "49",
pages = "328--332",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Effect of prostaglandin E in multiple experimental models. IV. Effect on resistance to endotoxin and tumor necrosis factor shock

AU - Waymack, J. Paul

AU - Moldawer, Lyle L.

AU - Lowry, Stephen F.

AU - Guzman, Rey F.

AU - Okerberg, Carlin V.

AU - Mason, Arthur D.

AU - Pruitt, Basil A

PY - 1990

Y1 - 1990

N2 - Administration of a long-acting prostaglandin E, 16,16-dimethyl-PGE (dPGE), to rats improves their survival of bacterial peritonitis. We examined the mechanism of this protective effect with reference to its interaction with the release of cachectin (TNF). Sixty rats received saline, 20 μg/kg dPGE, or 80 μg/kg dPGE 12 hr prior to endotoxin and continuing for 48 hr. Survival rates for the saline, 20 μg/kg dPGE, and 80 μg/kg dPGE groups were 0, 40, and 85%, respectively. Forty rats received saline or 80 μg/kg dPGE, with the initial dose being 3 hr following endotoxin challenge and continuing for 48 hr. Survival rates for both groups were 0%. Sixty rats received saline or 80 μg/kg dPGE at 12 and 1 hr prior to endotoxin. Two hours after challenge, they were sacrificed and plasma TNF levels were assayed. The plasma TNF level in saline-treated rats was 22.72 ± 0.83 ng/ml and in the dPGE-treated group, 16.03 ± 1.13 ng/ml (P < 0.001).

AB - Administration of a long-acting prostaglandin E, 16,16-dimethyl-PGE (dPGE), to rats improves their survival of bacterial peritonitis. We examined the mechanism of this protective effect with reference to its interaction with the release of cachectin (TNF). Sixty rats received saline, 20 μg/kg dPGE, or 80 μg/kg dPGE 12 hr prior to endotoxin and continuing for 48 hr. Survival rates for the saline, 20 μg/kg dPGE, and 80 μg/kg dPGE groups were 0, 40, and 85%, respectively. Forty rats received saline or 80 μg/kg dPGE, with the initial dose being 3 hr following endotoxin challenge and continuing for 48 hr. Survival rates for both groups were 0%. Sixty rats received saline or 80 μg/kg dPGE at 12 and 1 hr prior to endotoxin. Two hours after challenge, they were sacrificed and plasma TNF levels were assayed. The plasma TNF level in saline-treated rats was 22.72 ± 0.83 ng/ml and in the dPGE-treated group, 16.03 ± 1.13 ng/ml (P < 0.001).

UR - http://www.scopus.com/inward/record.url?scp=0025129762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025129762&partnerID=8YFLogxK

U2 - 10.1016/0022-4804(90)90031-V

DO - 10.1016/0022-4804(90)90031-V

M3 - Article

C2 - 2214741

AN - SCOPUS:0025129762

VL - 49

SP - 328

EP - 332

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 4

ER -