Effect of preload on rat aortic smooth muscle sensitivity to vasoactive agents

Jeremiah T. Herlihy, Peter V. Berardo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Concentration-response curves to potassium chloride, phenylephrine, serotonin and calcium chloride were obtained from rat aortic strips subjected to preloads of 0.75, 1.5 or 3.0 g. The sensitivity of the aortic smooth muscle to potassium chloride, phenylephrine and serotonin increased with increasing preload; whereas the calcium chloride concentration-response curves of K+-depolarized strips were unaffected by preload. These results demonstrate that the sensitivity of rat aortic smooth muscle to many vasoactive agents is a function of preload and also indicate that an alteration in the influx of external Ca2+ is not sufficient to explain the effect of preload on sensitivity.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
Issue number1
StatePublished - 1986


  • Calcium chloride
  • Phenylephrine
  • Potassium chloride
  • Serotonin
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Effect of preload on rat aortic smooth muscle sensitivity to vasoactive agents'. Together they form a unique fingerprint.

Cite this