Effect of platelet-rich plasma on bone healing of fresh frozen bone allograft in mandibular defects: A histomorphometric study in dogs

Michel R. Messora, Maria J.H. Nagata, Natália M. Pola, Natália de Campos, Stephen E. Fucini, Flávia A.C. Furlaneto

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: This study histologically analyzed the healing of fresh frozen bone allograft (FFBA) with or without platelet-rich plasma (PRP) in bony defects surgically created in the mandible of dogs. Material and methods: Bilateral resection defects were surgically created on the inferior border of the mandible in 10 dogs. The defects were randomly divided into three groups: C (the defect was filled by blood clot only), FFBA (the defect was filled with particulate FFBA), and FFBA/PRP (the defect was filled with particulate FFBA combined with PRP). The animals were euthanized at 12 weeks post-surgery. Histomorphometric and histological analyses were performed. Data were statistically analyzed using Friedman test and Dunn test (P < 0.05). Results: Group FFBA/PRP presented a statistically greater mineralized bone area and a smaller marrow bone area than Groups FFBA and C. Conclusions: The use of PRP improved the incorporation of FFBA, increasing the density of newly formed bone at 12 weeks post-surgery.

Original languageEnglish (US)
Pages (from-to)1347-1353
Number of pages7
JournalClinical oral implants research
Volume24
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Bone regeneration
  • Platelet-rich plasma
  • Transplantation, homologous

ASJC Scopus subject areas

  • Oral Surgery

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