Effect of plasma amino acid and hormone concentrations on renal plasma flow and glomerular filtration rate

Pietro Castellino, Ralph A. DeFronzo

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The effect of amino acid infusion on renal hemodynamics was examined in 13 healthy subjects. Seven subjects participated in the first experimental protocol: Study 1 -amino acids were infused for 3 h to increase plasma amino acid levels 2-to 3-fold above baseline; study 2 -amino acids were infused with somatostatin and peripheral replacement of insulin, glucagon and growth hormone; and study 3 -somatostatin and hormones were infused as in study 2, but no amino acids were infused. During study 1 both glomerular filtration rate (GFR) and renal plasma flow (RPF) increased by 20%. In contrast, when amino acids were infused with somatostatin (study 2), neither GFR nor RPF changed from baseline. In study 3, somatostatin alone had no effect on GFR and RPF. In a second experimental protocol, 6 subjects were maintained for 7 days on a low protein diet (40 g/day); amino acids were infused as in study 1 before and after the protein restric-tion. Baseline GFR and RPF both decreased significantly after protein restriction. The response to amino acid infusion was not changed. These results indicate that: (1) hyperaminoacidemia causes a rise in both GFR and RPF; (2) the increase is likely to be mediated by some hormones whose secretion is inhibited by somatostatin, and (3) protein restriction causes a decline in GFR and RPF but fails to alter the renal hemodynamic response to amino acid infusion.

Original languageEnglish (US)
Pages (from-to)240-249
Number of pages10
JournalBlood Purification
Volume6
Issue number4
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Keywords

  • Amino acid
  • Glomerular filtration rate
  • Low protein diet
  • Renal plasma flow
  • Somatostatin

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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