Effect of passive immunization with specific antiserum to FSH on the spermatogenic process and fertility of adult male bonnet monkeys (Macaca radiata)

The present study was undertaken to examine the effect of specific neutralization of FSH on the fertility and, in particular, testicular function in the adult male bonnet monkey. As long-term use of antisera to FSH raised in a heterologous species would lead to the formation of second antibody and other side effects, antiserum raised in monkeys against ovine FSH, characterized with respect to specificity and cross-reactivity with monkey FSH, was used for passive immunization in the same species. The parameters studied were fertility, relative density and quality of the ejaculated spermatozoa and certain biochemical processes in the testis to assess its function. In one group of monkeys, the effect of stopping the antiserum treatment on some of the above parameters was also studied.