Effect of partition coefficient, permeability surface product, and radioisotope on the signal-to-noise ratio in PET functional brain mapping: A computer simulation

Charles C. Martin, Paul A. Jerabek, Lisa D.H. Nickerson, Peter T. Fox, Charles C. Martin

Research output: Contribution to journalArticle

4 Scopus citations


In this work we use a computer simulation to estimate the magnitude of improvement in the signal-to-noise ratio of PET functional brain mapping studies as a function of partition coefficient and permeability surface product for O-14, F-17, and O-15 labeled flow tracers. A model for signal- to-noise ratio is derived from the Kety model for inert diffusible blood flow tracers. The results of the simulation suggest that moderate increases in partition coefficient and permeability surface product compared with water would lead to an increase in signal-to-noise ratio of a factor of about 3.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalHuman Brain Mapping
Issue number3
StatePublished - May 3 1999



  • Functional brain mapping
  • Positron emission tomography
  • Signal-to-noise ratio

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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