Effect of ocular perfusion pressure on retinal function in the rabbit

J. M. Harrison, J. W. Kiel, S. Smith

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The electroretinogram (ERG) vs perfusion pressure relation was studied in anesthetized rabbits during mechanically induced changes in mean arterial pressure (MAP). After 1 hr of dark adaptation, ERGs were obtained at perfusion pressures from 10 to 95 mmHg with each pressure held for 30-60 sec, and at three levels from 15 to 75 mmHg with each pressure held for 5 min. The slopes of the b-wave amplitude vs perfusion pressure data were not significantly different from zero during either the brief or longer manipulations of perfusion pressure. However, the b-wave was nearly extinguished 5 min after death. The results indicate that the rabbit ERG is maintained over a wide range of perfusion pressure.

Original languageEnglish (US)
Pages (from-to)2339-2347
Number of pages9
JournalVision Research
Volume37
Issue number17
DOIs
StatePublished - Sep 1997

Keywords

  • Choroid
  • Circulation
  • Electroretinogram (ERG)
  • Rabbit
  • Retina
  • b-wave

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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