Effect of millimeter waves on cyclophosphamide induced NF-κB

M. K. Logani, M. Natarajan, V. R. Makar, A. Bhanushali, M. C. Ziskin

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Abstract

Antiapoptotic activity of NF-Kappa B (NF-κB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-κB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-κB DNA-binding activity as compared to the control group. No significant enhancement in NF-κB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-κB induced by chemotherapeutic drugs.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalElectromagnetic Biology and Medicine
Volume25
Issue number1
DOIs
Publication statusPublished - Jun 1 2006

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Keywords

  • Chemotherapy
  • Cyclophosphamide
  • Millimeter waves
  • NF-Kappa B

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)

Cite this

Logani, M. K., Natarajan, M., Makar, V. R., Bhanushali, A., & Ziskin, M. C. (2006). Effect of millimeter waves on cyclophosphamide induced NF-κB. Electromagnetic Biology and Medicine, 25(1), 23-27. https://doi.org/10.1080/15368370600572946