Effect of millimeter waves on cyclophosphamide induced NF-κB

M. K. Logani; M. Natarajan; V. R. Makar; A. Bhanushali; M. C. Ziskin

doi:10.1080/15368370600572946

Effect of millimeter waves on cyclophosphamide induced NF-κB

M. K. Logani, M. Natarajan, V. R. Makar, A. Bhanushali, M. C. Ziskin

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Antiapoptotic activity of NF-Kappa B (NF-κB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-κB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-κB DNA-binding activity as compared to the control group. No significant enhancement in NF-κB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-κB induced by chemotherapeutic drugs.

Original language	English (US)
Pages (from-to)	23-27
Number of pages	5
Journal	Electromagnetic Biology and Medicine
Volume	25
Issue number	1
DOIs	https://doi.org/10.1080/15368370600572946
State	Published - Jun 1 2006
Externally published	Yes

Keywords

Chemotherapy
Cyclophosphamide
Millimeter waves
NF-Kappa B

ASJC Scopus subject areas

Biophysics
Medicine (miscellaneous)

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10.1080/15368370600572946

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title = "Effect of millimeter waves on cyclophosphamide induced NF-κB",

abstract = "Antiapoptotic activity of NF-Kappa B (NF-κB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-κB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-κB DNA-binding activity as compared to the control group. No significant enhancement in NF-κB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-κB induced by chemotherapeutic drugs.",

keywords = "Chemotherapy, Cyclophosphamide, Millimeter waves, NF-Kappa B",

author = "Logani, {M. K.} and M. Natarajan and Makar, {V. R.} and A. Bhanushali and Ziskin, {M. C.}",

note = "Funding Information: The authors are thankful to Dr. Stanislav Alekseev for dosimetry and to Dr. Imre Szabo for very helpful discussions. This work was supported by National Center for Complementary and Alternative Medicine, grant numbers RO1AT000492 and PO1AT002025. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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doi = "10.1080/15368370600572946",

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T1 - Effect of millimeter waves on cyclophosphamide induced NF-κB

AU - Logani, M. K.

AU - Natarajan, M.

AU - Makar, V. R.

AU - Bhanushali, A.

AU - Ziskin, M. C.

N1 - Funding Information: The authors are thankful to Dr. Stanislav Alekseev for dosimetry and to Dr. Imre Szabo for very helpful discussions. This work was supported by National Center for Complementary and Alternative Medicine, grant numbers RO1AT000492 and PO1AT002025. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/6/1

Y1 - 2006/6/1

N2 - Antiapoptotic activity of NF-Kappa B (NF-κB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-κB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-κB DNA-binding activity as compared to the control group. No significant enhancement in NF-κB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-κB induced by chemotherapeutic drugs.

AB - Antiapoptotic activity of NF-Kappa B (NF-κB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-κB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-κB DNA-binding activity as compared to the control group. No significant enhancement in NF-κB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-κB induced by chemotherapeutic drugs.

KW - Chemotherapy

KW - Cyclophosphamide

KW - Millimeter waves

KW - NF-Kappa B

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Effect of millimeter waves on cyclophosphamide induced NF-κB

Abstract

Keywords

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