Effect of methylmercury on the proteolytic activity of the erythrocyte membrane

E. Kielbasinska, R. Wierzbicki, M. Lasek, M. Gaczynska, G. Bartosz

Research output: Contribution to journalArticle

Abstract

Administration of methylmercuric chloride (MMC) to rats brought about an increase in the 'self-digestion' rate of membrane proteins during incubation of isolated membranes. This effect is due to an increase in the proteolytic susceptibility of membrane proteins rather than to activation of membraneous proteases, since degradation of an external substrate (azocasein) was decreased after exposure to MMC. These results indicate that MMC administration augments the susceptibility of membrane proteins to proteolysis by endogenous proteases.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalJournal of Trace Elements in Experimental Medicine
Volume3
Issue number4
StatePublished - Dec 1 1990

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Keywords

  • membrane proteins
  • proteolysis
  • spectrin

ASJC Scopus subject areas

  • Biochemistry

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