Administration of methylmercuric chloride (MMC) to rats brought about an increase in the 'self-digestion' rate of membrane proteins during incubation of isolated membranes. This effect is due to an increase in the proteolytic susceptibility of membrane proteins rather than to activation of membraneous proteases, since degradation of an external substrate (azocasein) was decreased after exposure to MMC. These results indicate that MMC administration augments the susceptibility of membrane proteins to proteolysis by endogenous proteases.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Trace Elements in Experimental Medicine|
|State||Published - Dec 1 1990|
- membrane proteins
ASJC Scopus subject areas